Mechanisms underlying corruption of working memory in Parkinson's disease.

Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101468753 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-6653 (Electronic) Linking ISSN: 17486645 NLM ISO Abbreviation: J Neuropsychol Subsets: MEDLINE

Publication: 2011- : Chichester : Wiley-Blackwell
Original Publication: Leicester : British Psychological Society, c2007-

Memory, Short-Term* ; Parkinson Disease*/complications; Humans ; Memory Disorders/etiology ; Mental Recall ; Attention

Working memory (WM) impairments are reported to occur in patients with Parkinson's disease (PD). However, the mechanisms are unclear. Here, we investigate several putative factors that might drive poor performance, by examining the precision of recall, the order in which items are recalled and whether memories are corrupted by random guessing (attentional lapses). We used two separate tasks that examined the quality of WM recall under different loads and retention periods, as well as a traditional digit span test. Firstly, on a simple measure of WM recall, where patients were asked to reproduce the orientation of a centrally presented arrow, overall recall was not significantly impaired. However, there was some evidence for increased guessing (attentional lapses). On a new analogue version of the Corsi-span task, where participants had to reproduce on a touchscreen the exact spatial pattern of presented stimuli in the order and locations in which they appeared, there was a reduction in the precision of spatial WM at higher loads. This deficit was due to misremembering item order. At the highest load, there was reduced recall precision, whereas increased guessing was only observed at intermediate set sizes. Finally, PD patients had impaired backward, but not forward, digit spans. Overall, these results reveal the task- and load-dependent nature of WM deficits in PD. On simple low-load tasks, attentional lapses predominate, whereas at higher loads, in the spatial domain, the corruption of mnemonic information-both order item and precision-emerge as the main driver of impairment.
(© 2023 The Authors. Journal of Neuropsychology published by John Wiley & Sons Ltd on behalf of The British Psychological Society.)

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United Kingdom WT_ Wellcome Trust; United Kingdom DH_ Department of Health

Keywords: Parkinson's disease; attention; misbinding; spatial span; working memory

Date Created: 20230116 Date Completed: 20230609 Latest Revision: 20230614

20231215

10.1111/jnp.12306

36642965