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Bioanalytical and non-targeted mass spectrometric screening for contaminants of emerging concern in Southern California bight sediments.
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- Author(s): Mehinto AC;Mehinto AC; Du B; Du B; Wenger E; Wenger E; Tian Z; Tian Z; Kolodziej EP; Kolodziej EP; Kolodziej EP; Kolodziej EP; Apeti D; Apeti D; Maruya KA; Maruya KA
- Source:
Chemosphere [Chemosphere] 2023 Aug; Vol. 331, pp. 138789. Date of Electronic Publication: 2023 Apr 26.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 0320657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1298 (Electronic) Linking ISSN: 00456535 NLM ISO Abbreviation: Chemosphere Subsets: MEDLINE
- Publication Information: Publication: Oxford : Elsevier Science Ltd
Original Publication: Oxford, New York, : Pergamon Press. - Subject Terms:
- Abstract: Assessing the impact of chemical contaminants on aquatic ecosystem health remains challenging due to complex exposure scenarios and the myriad of impact metrics to consider. To expand the breadth of compounds monitored and evaluate the potential hazard of environmental mixtures, cell-based bioassays (estrogen receptor alpha (ERα) and aryl hydrocarbon receptor (AhR)) and non-targeted chemical analyses with high resolution mass spectrometry (NTA-HRMS) were used to assess the quality of ∼70 marine sediment samples collected from 5 distinct coastal and offshore habitats of the Southern California Bight. AhR responses (<0.12-4.5 ng TCDD/g dry weight) were more frequently detectable and more variable than for ERα (<0.1-0.5 ng E2/g dry weight). The range of AhR and ERα responses increased by habitat as follows: Channel Islands < Mid-shelf < Marinas < Ports < Estuaries. The narrow range and magnitude of ERα screening response suggested limited potential for estrogenic impacts across sediments from all 5 habitats. The AhR response was positively correlated with total PAH and PCB concentrations and corresponded with a chemical score index representing the severity of metal and organic contamination. NTA-HRMS fingerprints generated in positive electrospray ionization mode were clearly distinguishable among coastal vs. offshore samples, with the greatest chemical complexity (n = 982 features detected) observed in estuarine sediment from a highly urbanized watershed (Los Angeles River). The concordance and complementary nature of bioscreening and NTA-HRMS results indicates their utility as holistic proxies for sediment quality, and when analyzed in conjunction with routine targeted chemical monitoring, show promise in identifying unexpected contaminants and novel toxicants.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.) - Contributed Indexing: Keywords: In vitro bioassays; Marine sediment; Sediment quality; Untargeted chemical analyses
- Accession Number: 0 (Estrogen Receptor alpha)
0 (Water Pollutants, Chemical) - Publication Date: Date Created: 20230428 Date Completed: 20231010 Latest Revision: 20231010
- Publication Date: 20231215
- Accession Number: 10.1016/j.chemosphere.2023.138789
- Accession Number: 37116726
- Source:
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