GDF11 as a friend or an enemy in the cancer biology?

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Author(s): Król W;Król W; Machelak W; Machelak W; Zielińska M; Zielińska M
  • Source:
    Biochimica et biophysica acta. Reviews on cancer [Biochim Biophys Acta Rev Cancer] 2023 Sep; Vol. 1878 (5), pp. 188944. Date of Electronic Publication: 2023 Jun 24.
  • Publication Type:
    Journal Article; Review; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9806362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2561 (Electronic) Linking ISSN: 0304419X NLM ISO Abbreviation: Biochim Biophys Acta Rev Cancer Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam : Elsevier
    • Subject Terms:
      Bone Morphogenetic Proteins*/metabolism ; Bone Morphogenetic Proteins*/pharmacology ; Neoplasms*; Male ; Humans ; Factor XI ; Growth Differentiation Factors/metabolism ; Growth Differentiation Factors/pharmacology ; Cell Differentiation ; Biology
    • Abstract:
      The Growth and Differential Factor 11 (GDF11) is a recently discovered representative of Transforming Growth Factor β superfamily. The highest expression of GDF11 is detected in the nervous system, bladder, seminal vesicles and muscles whereas the lowest in the testis, liver or breast. GDF11 role in physiology is still not clear. GDF11 is a crucial factor in embryogenesis, cell cycle control and apoptosis, inasmuch it mainly targets cell retain stemness features, managing to the cell differentiation and the maturation. GDF11 is entangled in lipid metabolism, inflammatory processes and aging. GDF11 is strongly related to carcinogenesis and its expression in tumors is intruded. GDF11 can promote cancer growth in the colon or inhibit the cell proliferation in breast cancer. The aberrated expression is probably allied with the impaired maturation. In this article we summarized an impact of GDF11 on the tumor cells and review the all attitudes connecting GDF11 with carcinogenesis.
      Competing Interests: Declaration of Competing Interest The authors declare that they have no competing interests.
      (Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Breast cancer; Cancer biology; GDF11; Liver cancer; Smad proteins; TGF-β pathway
    • Accession Number:
      0 (Bone Morphogenetic Proteins)
      9013-55-2 (Factor XI)
      0 (Growth Differentiation Factors)
      0 (GDF11 protein, human)
    • Publication Date:
      Date Created: 20230625 Date Completed: 20230907 Latest Revision: 20230922
    • Publication Date:
      20231215
    • Accession Number:
      10.1016/j.bbcan.2023.188944
    • Accession Number:
      37356738