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Lack of Stim2 Affects Vision-Dependent Behavior and Sensitivity to Hypoxia.
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- Author(s): Wasilewska I;Wasilewska I;Wasilewska I; Majewski Ł; Majewski Ł; Adamek-Urbańska D; Adamek-Urbańska D; Mondal SS; Mondal SS; Baranykova S; Baranykova S; Gupta RK; Gupta RK; Bielecki D; Bielecki D; Winata CL; Winata CL; Kuznicki J; Kuznicki J
- Source:
Zebrafish [Zebrafish] 2023 Aug; Vol. 20 (4), pp. 146-159.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101225070 Publication Model: Print Cited Medium: Internet ISSN: 1557-8542 (Electronic) Linking ISSN: 15458547 NLM ISO Abbreviation: Zebrafish Subsets: MEDLINE
- Publication Information: Original Publication: Larchmont, NY : Mary Ann Liebert, Inc., c2004-
- Subject Terms:
- Abstract: Stromal interaction molecules (STIMs) are endoplasmic reticulum-resident proteins that regulate Ca 2+ homeostasis and signaling by store-operated calcium entry (SOCE). The different properties and functions of STIM1 and STIM2 have been described mostly based on work in vitro . STIM2 knockout mice do not survive until adulthood. Therefore, we generated and characterized stim2a and stim2b double-knockout zebrafish. The ( stim2a;stim2b ) -/- zebrafish did not have any apparent morphological phenotype. However, RNA sequencing revealed 1424 differentially expressed genes. One of the most upregulated genes was annexin A3a , which is a marker of activated microglia. This corresponded well to an increase in Neutral Red staining in the in vivo imaging of the ( stim2a;stim2b ) -/- zebrafish brain. The lack of Stim2 decreased zebrafish survival under low oxygen conditions. Behavioral tests, such as the visual-motor response test and dark-light preference test, indicated that ( stim2a;stim2b ) -/- larvae might have problems with vision. This was consistent with the downregulation of many genes that are related to light perception. The periodic acid-Schiff staining of retina sections from adult zebrafish revealed alterations of the stratum pigmentosum, suggesting the involvement of a Stim2-dependent process in visual perception. Altogether, these data reveal new functions for Stim2 in the nervous system.
- Contributed Indexing: Keywords: SOCE; Stim2; behavior; hypoxia; retina; zebrafish
- Accession Number: 0 (Stim2 protein, mouse)
0 (Stromal Interaction Molecule 2) - Publication Date: Date Created: 20230817 Date Completed: 20230821 Latest Revision: 20231004
- Publication Date: 20240514
- Accession Number: 10.1089/zeb.2022.0068
- Accession Number: 37590563
- Source:
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