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A perspective on translating genomic discoveries into targets for brain-machine interface and deep brain stimulation devices.
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- Author(s): Valentim WL;Valentim WL;Valentim WL; Tylee DS; Tylee DS; Tylee DS; Polimanti R; Polimanti R; Polimanti R
- Source:
WIREs mechanisms of disease [WIREs Mech Dis] 2024 Mar-Apr; Vol. 16 (2), pp. e1635. Date of Electronic Publication: 2023 Dec 07.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 9918227353306676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2692-9368 (Electronic) Linking ISSN: 26929368 NLM ISO Abbreviation: WIREs Mech Dis Subsets: MEDLINE
- Publication Information: Original Publication: [Hoboken, NJ] : John Wiley & Sons, Inc., [2021]-
- Subject Terms:
- Abstract: Mental illnesses have a huge impact on individuals, families, and society, so there is a growing need for more efficient treatments. In this context, brain-computer interface (BCI) technology has the potential to revolutionize the options for neuropsychiatric therapies. However, the development of BCI-based therapies faces enormous challenges, such as power dissipation constraints, lack of credible feedback mechanisms, uncertainty of which brain areas and frequencies to target, and even which patients to treat. Some of these setbacks are due to the large gap in our understanding of brain function. In recent years, large-scale genomic analyses uncovered an unprecedented amount of information regarding the biology of the altered brain function observed across the psychopathology spectrum. We believe findings from genetic studies can be useful to refine BCI technology to develop novel treatment options for mental illnesses. Here, we assess the latest advancements in both fields, the possibilities that can be generated from their intersection, and the challenges that these research areas will need to address to ensure that translational efforts can lead to effective and reliable interventions. Specifically, starting from highlighting the overlap between mechanisms uncovered by large-scale genetic studies and the current targets of deep brain stimulation treatments, we describe the steps that could help to translate genomic discoveries into BCI targets. Because these two research areas have not been previously presented together, the present article can provide a novel perspective for scientists with different research backgrounds. This article is categorized under: Neurological Diseases > Genetics/Genomics/Epigenetics Neurological Diseases > Biomedical Engineering.
(© 2023 Wiley Periodicals LLC.) - Grant Information: R21 DC018098 United States NH NIH HHS; R33 DA047527 United States NH NIH HHS; RF1MH132337 United States NH NIH HHS; R21 DC018098 United States NH NIH HHS; R33 DA047527 United States NH NIH HHS; RF1MH132337 United States NH NIH HHS
- Contributed Indexing: Keywords: brain function; brain-machine interface; genome-wide association studies; neuropsychiatric disorders; translational research
- Publication Date: Date Created: 20231207 Date Completed: 20240315 Latest Revision: 20240605
- Publication Date: 20240605
- Accession Number: 10.1002/wsbm.1635
- Accession Number: 38059513
- Source:
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