Fabrication of Novel 3-D Nanocomposites of HAp-TiC-h-BN-ZrO 2 : Enhanced Mechanical Performances and In Vivo Toxicity Study for Biomedical Applications.

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  • Additional Information
    • Source:
      Publisher: American Chemical Society Country of Publication: United States NLM ID: 101654670 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-9878 (Electronic) Linking ISSN: 23739878 NLM ISO Abbreviation: ACS Biomater Sci Eng Subsets: MEDLINE
    • Publication Information:
      Original Publication: Washington, DC : American Chemical Society, [2015]-
    • Subject Terms:
      Durapatite*/toxicity ; Durapatite*/chemistry ; Nanocomposites*/toxicity; Rats ; Animals ; Rats, Sprague-Dawley ; Biocompatible Materials/toxicity ; Bone and Bones
    • Abstract:
      Due to excellent biocompatibility, bioactivities, and osteoconductivity, hydroxyapatite (HAp) is considered as one of the most suitable biomaterials for numerous biomedical applications. Herein, HAp was fabricated using a bottom-up approach, i.e., a wet chemical method, and its composites with TiC, h-BN, and ZrO 2 were fabricated by a solid-state reaction method with enhanced mechanical and biological performances. Structural, surface morphology, and mechanical behavior of the fabricated composites were characterized using various characterization techniques. Furthermore, transmission electron microscopy study revealed a randomly oriented rod-like morphology, with the length and width of these nanorods ranging from 78 to 122 and from 9 to 13 nm. Moreover, the mechanical characterizations of the composite HZBT4 (80HAp-10TiC-5h-BN-5ZrO 2 ) reveal a very high compressive strength (246 MPa), which is comparable to that of the steel (250 MPa), fracture toughness (14.78 MPa m 1/2 ), and Young's modulus (1.02 GPa). In order to check the biocompatibility of the composites, numerous biological tests were also performed on different body organs of healthy adult Sprague-Dawley rats. This study suggests that the composite HZBT4 could not reveal any significant influence on the hematological, serum biochemical, and histopathological parameters. Hence, the fabricated composite can be used for several biological applications, such as bone implants, bone grafting, and bone regeneration.
    • Contributed Indexing:
      Keywords: composites; hydroxyapatite; in vivo study; mechanical performances; morphology
    • Accession Number:
      91D9GV0Z28 (Durapatite)
      0 (Biocompatible Materials)
    • Publication Date:
      Date Created: 20240318 Date Completed: 20240409 Latest Revision: 20240612
    • Publication Date:
      20240613
    • Accession Number:
      10.1021/acsbiomaterials.3c01478
    • Accession Number:
      38498674