Genetic Tools for Cell Lineage Tracing and Profiling Developmental Trajectories in the Skin.

Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print Cited Medium: Internet ISSN: 1523-1747 (Electronic) Linking ISSN: 0022202X NLM ISO Abbreviation: J Invest Dermatol Subsets: MEDLINE

Publication: 2016- : New York : Elsevier
Original Publication: Baltimore, Williams & Wilkins.

Cell Lineage* ; Cell Differentiation*; Humans ; Animals ; Skin/cytology ; Stem Cells/cytology ; Cell Proliferation ; Regeneration/physiology

The epidermis is the body's first line of protection against dehydration and pathogens, continually regenerating the outermost protective skin layers throughout life. During both embryonic development and wound healing, epidermal stem and progenitor cells must respond to external stimuli and insults to build, maintain, and repair the cutaneous barrier. Recent advances in CRISPR-based methods for cell lineage tracing have remarkably expanded the potential for experiments that track stem and progenitor cell proliferation and differentiation over the course of tissue and even organismal development. Additional tools for DNA-based recording of cellular signaling cues promise to deepen our understanding of the mechanisms driving normal skin morphogenesis and response to stressors as well as the dysregulation of cell proliferation and differentiation in skin diseases and cancer. In this review, we highlight cutting-edge methods for cell lineage tracing, including in organoids and model organisms, and explore how cutaneous biology researchers might leverage these techniques to elucidate the developmental programs that support the regenerative capacity and plasticity of the skin.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Science. 2014 Nov 28;346(6213):1258096. (PMID: 25430774)
Nature. 2013 Dec 12;504(7479):277-281. (PMID: 24336287)
Cell Stem Cell. 2020 Sep 3;27(3):383-395.e8. (PMID: 32783885)
Nat Biotechnol. 2023 Sep 25;:. (PMID: 37749269)
Nat Med. 2013 Jul;19(7):916-23. (PMID: 23727932)
Nat Commun. 2017 Mar 01;8:14684. (PMID: 28248284)
Dev Cell. 2024 Jan 22;59(2):187-198.e7. (PMID: 38198888)
Blood. 2010 Apr 1;115(13):2610-8. (PMID: 20093403)
Science. 2016 Jul 1;353(6294):78-82. (PMID: 27365449)
Elife. 2020 Apr 20;9:. (PMID: 32310087)
Nature. 2007 Nov 1;450(7166):56-62. (PMID: 17972876)
Science. 2016 Jul 29;353(6298):aaf7907. (PMID: 27229144)
Nat Biotechnol. 2020 Jan;38(1):66-75. (PMID: 31740838)
Nature. 2016 May 19;533(7603):420-4. (PMID: 27096365)
Int J Mol Sci. 2022 Apr 30;23(9):. (PMID: 35563412)
Nat Rev Mol Cell Biol. 2024 Feb;25(2):87-100. (PMID: 37903969)
Science. 2021 Apr 9;372(6538):. (PMID: 33833095)
Cell. 2023 Aug 31;186(18):3983-4002.e26. (PMID: 37657419)
Nat Med. 2017 Dec;23(12):1488-1498. (PMID: 29131159)
Nature. 2022 Aug;608(7921):98-107. (PMID: 35794474)
J Clin Invest. 2009 Jun;119(6):1420-8. (PMID: 19487818)
Methods Mol Biol. 2010;585:127-46. (PMID: 19908001)
Nat Commun. 2019 Mar 15;10(1):1234. (PMID: 30874552)
Nat Methods. 2017 Feb;14(2):195-200. (PMID: 27918539)
Nat Rev Cancer. 2013 Mar;13(3):161-71. (PMID: 23388619)
Sci Adv. 2021 Apr 14;7(16):. (PMID: 33853780)
Science. 2021 Feb 26;371(6532):. (PMID: 33479121)
Nature. 2019 Jun;570(7759):77-82. (PMID: 31086336)
Surg Pathol Clin. 2021 Jun;14(2):251-272. (PMID: 34023104)
Cell. 2021 Oct 28;184(22):5635-5652.e29. (PMID: 34653350)
Dev Cell. 2021 Jan 11;56(1):7-21. (PMID: 33217333)
Nature. 2012 Jul 26;487(7408):496-9. (PMID: 22763436)
Nature. 2017 Jan 5;541(7635):107-111. (PMID: 27869821)
J Invest Dermatol. 2019 Nov;139(11):2263-2271.e5. (PMID: 31207229)
N Engl J Med. 2021 Jan 21;384(3):252-260. (PMID: 33283989)
Nature. 2023 Sep;621(7978):365-372. (PMID: 36198796)
Nat Commun. 2020 Nov 11;11(1):5701. (PMID: 33177522)
Cell Rep. 2018 Oct 16;25(3):585-597.e7. (PMID: 30332640)
Trends Pharmacol Sci. 2018 Sep;39(9):783-784. (PMID: 30006230)
Nature. 2020 Jun;582(7812):399-404. (PMID: 32494013)
Nat Rev Cancer. 2012 Feb 24;12(3):170-80. (PMID: 22362215)
Nature. 2014 Oct 16;514(7522):322-7. (PMID: 25296256)
Front Cardiovasc Med. 2023 Feb 27;10:1085629. (PMID: 36923960)
J Invest Dermatol. 2018 Apr;138(4):720-725. (PMID: 29579452)
Nat Protoc. 2020 Mar;15(3):750-772. (PMID: 32051617)
Nat Biotechnol. 2011 Oct 02;29(10):928-33. (PMID: 21964413)
Science. 2021 Apr 23;372(6540):. (PMID: 33888614)
Nat Methods. 2022 Jan;19(1):90-99. (PMID: 34969984)
Mol Cell. 2019 Aug 22;75(4):769-780.e4. (PMID: 31442423)
J Invest Dermatol. 2016 Sep;136(9):e87-e93. (PMID: 27542298)
Nat Biotechnol. 2014 Oct;32(10):1053-8. (PMID: 25086649)
Trends Biotechnol. 2023 Aug;41(8):1000-1012. (PMID: 37002157)
Curr Top Dev Biol. 2016;116:357-74. (PMID: 26970628)
Nat Genet. 1999 Apr;21(4):410-3. (PMID: 10192393)
Science. 2004 Jan 16;303(5656):359-63. (PMID: 14671312)
J Invest Dermatol. 2004 Jan;122(1):1-6. (PMID: 14962082)
Nat Biotechnol. 2018 Jun;36(5):469-473. (PMID: 29644996)
Nat Med. 2015 May;21(5):440-8. (PMID: 25849130)
Gastrointest Cancer Res. 2007 Nov;1(6):229-35. (PMID: 19262901)
Science. 2014 Nov 21;346(6212):941-5. (PMID: 25414301)
Exp Dermatol. 2021 Jan;30(1):92-101. (PMID: 33237598)
Cell. 2023 May 11;186(10):2256-2272.e23. (PMID: 37119812)
Curr Gene Ther. 2016;16(3):156-67. (PMID: 27216914)
Nat Commun. 2020 Aug 27;11(1):4307. (PMID: 32855414)
Nat Protoc. 2021 Feb;16(2):1089-1128. (PMID: 33462442)
Cell. 1990 Jun 29;61(7):1329-37. (PMID: 2364430)
J Clin Invest. 2022 Apr 1;132(7):. (PMID: 35143422)
Cell. 2017 May 4;169(4):636-650.e14. (PMID: 28434617)
Genome Biol. 2020 Apr 14;21(1):92. (PMID: 32290857)
Nat Commun. 2021 Feb 17;12(1):1088. (PMID: 33597522)
Cell Mol Gastroenterol Hepatol. 2018 Feb 13;5(4):539-548. (PMID: 29713661)
Dev Biol. 1983 Nov;100(1):64-119. (PMID: 6684600)
Hum Gene Ther. 2001 Oct 10;12(15):1893-905. (PMID: 11589831)
Cell. 2001 May 18;105(4):533-45. (PMID: 11371349)
Science. 2018 Apr 13;360(6385):. (PMID: 29449507)
BioData Min. 2010 Feb 22;3(1):1. (PMID: 20175922)
Nat Biotechnol. 2024 Feb;42(2):253-264. (PMID: 37142705)
Nature. 2019 Dec;576(7785):149-157. (PMID: 31634902)
Nat Biotechnol. 2023 Aug;41(8):1151-1159. (PMID: 36646933)
Nature. 2016 Aug 18;536(7616):298-303. (PMID: 27459053)
Cell. 2020 Jun 11;181(6):1410-1422.e27. (PMID: 32413320)
Cell Rep. 2023 May 30;42(5):112511. (PMID: 37195865)
Cancer Cell. 2021 Aug 9;39(8):1150-1162.e9. (PMID: 34115987)
Nature. 2017 Nov 23;551(7681):464-471. (PMID: 29160308)
J Invest Dermatol. 2012 Feb;132(2):401-9. (PMID: 22011906)
J Invest Dermatol. 2016 Aug;136(8):1543-1548. (PMID: 27160068)
Nature. 2007 Mar 8;446(7132):185-9. (PMID: 17330052)
Mol Cell Proteomics. 2020 May;19(5):744-756. (PMID: 32132232)
Nat Rev Genet. 2023 Aug;24(8):550-572. (PMID: 37002403)
Differentiation. 1975 Aug 11;3(1-3):161-5. (PMID: 1237438)
Cold Spring Harb Perspect Biol. 2022 Jul 1;14(7):. (PMID: 34607830)
Cell Stem Cell. 2017 Nov 2;21(5):665-678.e6. (PMID: 29033353)
Science. 2022 Oct 14;378(6616):eabm5874. (PMID: 36227997)
Cells. 2019 Jul 30;8(8):. (PMID: 31366153)
Elife. 2020 Mar 17;9:. (PMID: 32178760)
Nat Methods. 2016 Oct;13(10):845-8. (PMID: 27571553)
Biomaterials. 2020 Oct;255:120201. (PMID: 32592872)
Mol Ther. 2021 Nov 3;29(11):3103-3106. (PMID: 34710352)
Science. 2016 Sep 09;353(6304):. (PMID: 27540006)
Nat Commun. 2019 Feb 8;10(1):650. (PMID: 30737373)
Nat Struct Mol Biol. 2013 Mar;20(3):282-9. (PMID: 23463313)
Cell. 2022 May 26;185(11):1905-1923.e25. (PMID: 35523183)
Nat Med. 2018 Jul;24(7):927-930. (PMID: 29892067)
Cell. 2023 Nov 9;186(23):5183-5199.e22. (PMID: 37852258)
Nat Chem Biol. 2021 Jun;17(6):739-747. (PMID: 33753928)
Sci Rep. 2017 Sep 19;7(1):11838. (PMID: 28928444)
Nat Cell Biol. 2019 Aug;21(8):924-932. (PMID: 31358966)
ACS Synth Biol. 2017 Jun 16;6(6):936-942. (PMID: 28264564)
Sci Rep. 2020 Jun 1;10(1):8867. (PMID: 32483262)
Cancer Metastasis Rev. 2023 Nov 1;:. (PMID: 37910295)
Nat Protoc. 2018 Apr;13(4):599-604. (PMID: 29494575)
Nat Methods. 2011 Mar;8(3):253-9. (PMID: 21297621)
Hum Gene Ther. 1996 Nov 10;7(17):2101-12. (PMID: 8934224)
Nat Protoc. 2020 Apr;15(4):1484-1506. (PMID: 32103204)
Nat Biotechnol. 2010 Oct;28(10):1079-88. (PMID: 20944600)
Dis Model Mech. 2013 May;6(3):828-33. (PMID: 23519027)
Nat Biotechnol. 2018 Jun;36(5):442-450. (PMID: 29608178)
Nucleic Acids Res. 2012 Oct;40(19):e150. (PMID: 22753106)
Science. 2022 Aug 5;377(6606):eabn5800. (PMID: 35926038)
Nat Cell Biol. 2022 Dec;24(12):1692-1700. (PMID: 36357619)
Mol Cancer. 2020 Apr 27;19(1):79. (PMID: 32340605)
Curr Opin Chem Biol. 2019 Oct;52:63-71. (PMID: 31212208)
Cold Spring Harb Perspect Med. 2014 Jan 01;4(1):a015206. (PMID: 24384814)
BMC Biotechnol. 2006 Nov 03;6:43. (PMID: 17083727)
Nat Cell Biol. 2016 Jun;18(6):619-31. (PMID: 27183471)
Nat Biotechnol. 2023 Oct;41(10):1446-1456. (PMID: 36797492)

K08 AR075846 United States AR NIAMS NIH HHS

Keywords: CRISPR; DNA barcoding; DNA typewriter; Genome editing; Prime editor

Date Created: 20240421 Date Completed: 20240423 Latest Revision: 20240426

20240426

PMC11034889

10.1016/j.jid.2024.02.006

38643988