Nonlinear relationship between viral load and TCT in single/multiple HPV52 infection.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read Online Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101231645 Publication Model: Electronic Cited Medium: Internet ISSN: 1743-422X (Electronic) Linking ISSN: 1743422X NLM ISO Abbreviation: Virol J Subsets: MEDLINE
    • Publication Information:
      Original Publication: [London] : BioMed Central, 2004-
    • Subject Terms:
      Human Papillomavirus Viruses*/classification ; Human Papillomavirus Viruses*/isolation & purification ; Papillomavirus Infections*/virology ; Papillomavirus Infections*/diagnosis ; Uterine Cervical Neoplasms*/virology ; Uterine Cervical Neoplasms*/diagnosis ; Viral Load*; Adult ; Aged ; Female ; Humans ; Middle Aged ; Young Adult ; Coinfection/virology ; DNA, Viral/genetics ; Early Detection of Cancer/methods ; Genotype ; Uterine Cervical Dysplasia/virology ; Uterine Cervical Dysplasia/diagnosis ; Vaginal Smears
    • Abstract:
      Purpose: To determine the correlation between HPV (human papillomavirus) 52 viral load, multiple infections and ThinPrep cytology test (TCT), to inform clinical management of HPV52-positive women after cervical cancer screening.
      Methods: A total of 1,882 female patients who had positive quantitative HPV tests at Yuebei People's Hospital from January 2020 to December 2022, of whom 533 tested positive for HPV52. We excluded patients who combined HPV16 and/or HPV 18 positivity and whom HPV52 viral load could not be calculated. The final enrollment was 488 patients, including 400 NILM, 48 ASC-US, 28 LSIL and 12 HSIL. The HPV test is a quantitative multiplexed fluorescent PCR assay that provides both HPV genotyping and viral load.
      Results: In our study, there were differences in the median distribution of viral loads among various cytological class categories. The risk of TCT results (LSIL or worse) was increased with the increase of HPV52 viral load, for every LOG unit increase in HPV52 viral load, the risk increased by 26.6%. More importantly, we found a nonlinear relationship between HPV52 viral load and TCT results (LSIL or worse) in both single and multiple infections. When the viral load reaches a threshold, the risk of abnormal cytological results increases significantly.
      Conclusion: HPV52 viral load is an independent risk factor for TCT results (LSIL or worse). The relationship between HPV52 viral load and TCT results (LSIL or worse) is not linear. Viral load may be used as a triage indicator for HPV52-positive patients, thus improving the post-screening clinical management of HPV52-positive women.
      (© 2024. The Author(s).)
    • References:
      Eur J Cancer. 2001 Oct;37 Suppl 8:S4-66. (PMID: 11602373)
      Cancer Epidemiol Biomarkers Prev. 2019 Nov;28(11):1816-1824. (PMID: 31488417)
      J Clin Virol. 2018 Feb - Mar;99-100:79-83. (PMID: 29353074)
      Virology. 2010 May 25;401(1):70-9. (PMID: 20206957)
      Int J Mol Sci. 2023 Jan 10;24(2):. (PMID: 36674835)
      Clin Chim Acta. 2018 Aug;483:249-255. (PMID: 29752912)
      BMC Cancer. 2022 Jan 6;22(1):42. (PMID: 34991494)
      J Infect Dis. 2019 Jan 7;219(2):215-222. (PMID: 31067317)
      Cancer Epidemiol Biomarkers Prev. 2010 Mar;19(3):832-7. (PMID: 20200441)
      J Clin Oncol. 2016 Mar 20;34(9):987-1011. (PMID: 26846975)
      Gynecol Oncol. 2019 Nov;155(2):245-253. (PMID: 31604665)
      Acta Cytol. 2015;59(5):391-8. (PMID: 26674365)
      CA Cancer J Clin. 2018 Nov;68(6):394-424. (PMID: 30207593)
      Cancer Cytopathol. 2022 Apr;130(4):248-258. (PMID: 34874615)
      J Med Virol. 2017 Mar;89(3):535-541. (PMID: 27464021)
      Int J Gynecol Cancer. 2008 Jan-Feb;18(1):71-9. (PMID: 17466054)
      J Med Virol. 2019 Mar;91(3):473-481. (PMID: 30281807)
      CA Cancer J Clin. 2021 May;71(3):209-249. (PMID: 33538338)
      JAMA Netw Open. 2019 Nov 1;2(11):e1915781. (PMID: 31747033)
      Viruses. 2020 Mar 31;12(4):. (PMID: 32244347)
      Sci Rep. 2022 Aug 3;12(1):13353. (PMID: 35922661)
      J Low Genit Tract Dis. 2017 Jan;21(1):12-16. (PMID: 27851695)
      Ann Oncol. 2011 Dec;22(12):2675-2686. (PMID: 21471563)
      BMC Womens Health. 2021 Oct 8;21(1):353. (PMID: 34625069)
      J Clin Microbiol. 2013 May;51(5):1458-64. (PMID: 23447632)
      Emerg Microbes Infect. 2023 Dec;12(1):e2176009. (PMID: 36744409)
      Nature. 2012 Aug 30;488(7413):S2-3. (PMID: 22932437)
      J Pathol. 2007 Aug;212(4):356-67. (PMID: 17573670)
      IARC Monogr Eval Carcinog Risks Hum. 2012;100(Pt B):1-441. (PMID: 23189750)
      Gynecol Oncol. 2018 Jan;148(1):103-110. (PMID: 29169614)
    • Contributed Indexing:
      Keywords: HPV viral load; Multiple HPV infections; Single HPV infection; TCT
    • Accession Number:
      0 (DNA, Viral)
    • Subject Terms:
      human papillomavirus 52
    • Publication Date:
      Date Created: 20240423 Date Completed: 20240424 Latest Revision: 20240513
    • Publication Date:
      20240514
    • Accession Number:
      PMC11036758
    • Accession Number:
      10.1186/s12985-024-02356-4
    • Accession Number:
      38654353