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Adolescent Male Rats Exposed to Social Defeat Exhibit Altered Anxiety. Behavior and Limbic Monoamines as Adult.
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- Author(s): Watt, Michael J.1 ; Burke, Andrew R.1; Renner, Kenneth J.1; Forster, Gina L.1
- Source:
Behavioral Neuroscience. Jun2009, Vol. 123 Issue 3, p564-576. 13p.- Subject Terms:
- Source:
- Additional Information
- Abstract: Social stress in adolescence is correlated with emergence of psychopathologies, during early adulthood. In this study, the authors investigated the impact of social defeat stress during mid-adolescence on adult male brain and behavior. Adolescent male Sprague-Dawley rats were exposed to repeated social defeat for 5 days while controls were placed in a novel empty cage. When exposed to defeat-associated rues as adults, previously defeated rats showed increased risk assessment and behavioral inhibition, demonstrating long-term memory for the defeat context. However, previously defeated rats exhibited increased, locomotion in both elevated plus-maze and open field tests, suggesting heightened novelty-induced behavior. Adolescent defeat also affected adult monoamine levels in stress-responsive limbic regions, causing decreased medial prefrontal cortex dopamine, increased norepinephrine and serotonin in the ventral dentate gyms, and decreased norepinephrine in the dorsal raphe. Our results suggest that adolescent social defeat produces both deficits in anxiety responses and altered monoaminergic function in adulthood. This model offers potential for identifying specific mechanisms induced by severe adolescent social stress that may contribute to increased adult male vulnerability to psychopathology. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Behavioral Neuroscience is the property of American Psychological Association and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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