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Wando Mount Pleasant Library
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Phone: (843) 805-6888
Main Library
2 p.m. – 5 p.m.
Phone: (843) 805-6930
McClellanville Library
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Phone: (843) 887-3699
Folly Beach Library
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Phone: (843) 588-2001
Miss Jane's Building (Edisto Library Temporary Location)
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West Ashley Library
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Phone: (843) 766-6635
John L. Dart Library
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St. Paul's/Hollywood Library
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John's Island Library
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Effect of Aspirin on Nuclear β-Catenin Expression in Sporadic Colorectal Adenomas. (English)
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- Author(s): Hee Jung Kim; Sung Joon Lee; Sung Chul Park; Dae Hee Choi; Chang Don Kang; Gu Kang
- Source:
Intestinal Research; 2013, Vol. 11 Issue 4, p283-291, 9p- Subject Terms:
- Source:
- Additional Information
- Abstract: Background/Aims: In addition to the inhibition of cyclooxygenase-2, the chemopreventive effect of non-steroidal anti-inflammatory drugs on the nuclear translocation of β-catenin has been suggested in patients with familial adenoma polyposis. We investigated the effect of aspirin on the β-catenin signaling pathway in patients with sporadic colorectal adenoma. Methods: We selected patients diagnosed with colorectal adenoma. Patients who had been taking aspirin for more than 12 months were identified as the aspirin group, and those who did not were the non-aspirin group. Their characteristics, including size and degree of dysplasia, were compared. Immunohistochemical staining was conducted and the expression levels of nuclear β-catenin and cyclin D1 were investigated. Results: The median duration of aspirin intake was 37 months; there were no significant differences in the size, histological type, and degree of dysplasia between the two groups. Nuclear β-catenin expression was observed in 43.2% of the patients in the aspirin group and in 18.9% of those in the non-aspirin group (P < 0.05). There was no significant difference in nuclear cyclin D1 staining between the aspirin (78.4%) and non-aspirin (91.9%) groups. Conclusions: In this retrospective study, nuclear β-catenin expression in sporadic colorectal adenoma in the aspirin group was not inhibited compared with that in the non-aspirin group. Therefore, further prospective studies with a large number of patients are necessary. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Intestinal Research is the property of Korean Association for the Study of Intestinal Diseases and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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