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Phone: (843) 869-2355
Main Library
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Phone: (843) 805-6930
West Ashley Library
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Phone: (843) 766-6635
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Estimating the risk of aflatoxin-induced liver cancer in Tanzania based on biomarker data.
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- Author(s): Kimanya, Martin E.1 (AUTHOR); Routledge, Michael N.2,3 (AUTHOR); Mpolya, Emmanuel1 (AUTHOR); Ezekiel, Chibundu N.4 (AUTHOR); Shirima, Candida P.5 (AUTHOR); Gong, Yun Yun6 (AUTHOR)
- Source:
PLoS ONE. 3/11/2021, Vol. 16 Issue 3, p1-11. 11p.- Subject Terms:
- Source:
- Additional Information
- Subject Terms:
- Abstract: Evidence about the magnitude of the aflatoxin menace can help policy makers appreciate the importance of the problem and strengthen policies to support aflatoxin mitigation measures. In this study, we estimated aflatoxin-induced liver cancer risk in 2016 for Tanzania and used the information to estimate the health burden due to the aflatoxin exposure in the country. The burden of aflatoxin-induced liver cancer was assessed based on available aflatoxin biomarker data from a previous epidemiology study, hepatitis B virus infection prevalence and population size of Tanzania in 2016. The health burden due to aflatoxin-induced liver cancer was estimated using disability adjusted life years (DALYs). The aflatoxin exposures ranged from 15.0–10,926.0 ng/kg bw/day (median, 105.5 ng/kg bw/day). We estimated that in 2016 there were about 1,480 (2.95 per 100,000 persons) new cases of aflatoxin-induced liver cancer in Tanzania and assumed all of them would die within a year. These morbidity and mortality rates led to a total loss of about 56,247.63 DALYs. These results show, quantitatively, the cases of liver cancer and related deaths that could be avoided, and the healthy life years that could be saved, annually, by strengthening measures to control aflatoxin contamination in Tanzania. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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