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McClellanville Library
9 a.m. – 1 p.m.
Phone: (843) 887-3699
Folly Beach Library
9 a.m. - 2 p.m.
Phone: (843) 588-2001
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. – 1 p.m.
Phone: (843) 869-2355
Main Library
Closed (2024 Early Election)
Phone: (843) 805-6930
West Ashley Library
9 a.m. - 5 p.m.
Phone: (843) 766-6635
John L. Dart Library
9 a.m. - 5 p.m.
Phone: (843) 722-7550
St. Paul's/Hollywood Library
Closed (Early Voting)
Phone: (843) 889-3300
Mt. Pleasant Library
9 a.m. – 5 p.m.
Phone: (843) 849-6161
Dorchester Road Library
9 a.m. - 5 p.m.
Phone: (843) 552-6466
Edgar Allan Poe/Sullivan's Island Library
9 a.m. - 1 p.m.
Phone: (843) 883-3914
John's Island Library
9 a.m. - 5 p.m.
Phone: (843) 559-1945
Wando Mount Pleasant Library
9 a.m. - 5 p.m.
Phone: (843) 805-6888
Otranto Road Library
9 a.m. - 5 p.m.
Phone: (843) 572-4094
Hurd/St. Andrews Library
9 a.m. - 5 p.m.
Phone: (843) 766-2546
Baxter-Patrick James Island
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Phone: (843) 795-6679
Bees Ferry West Ashley Library
9 a.m. - 5 p.m.
Phone: (843) 805-6892
Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
Keith Summey North Charleston Library
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Phone: (843) 744-2489
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Closed
Phone: (843) 805-6909
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Tumor-associated antigen PRAME exhibits dualistic functions that are targetable in diffuse large B cell lymphoma.
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- Author(s): Katsuyoshi Takata1,2; Chong, Lauren C.1; Daisuke Ennishi1; Tomohiro Aoki1; Li, Michael Yu1; Thakur, Avinash3,4; Healy, Shannon1; Viganò, Elena1; Tao Dao5; Kwon, Daniel6; Duns, Gerben1; Nielsen, Julie S.7; Ben-Neriah, Susana1; Tse, Ethan1; Hung, Stacy S.1; Boyle, Merrill1; Sung Soo Mun5; Bourne, Christopher M.5; Woolcock, Bruce1; Telenius, Adèle1
- Source:
Journal of Clinical Investigation. 5/16/2022, Vol. 132 Issue 10, p1-15. 15p.- Subject Terms:
- Source:
- Additional Information
- Abstract: PRAME is a prominent member of the cancer testis antigen family of proteins, which triggers autologous T cell-mediated immune responses. Integrative genomic analysis in diffuse large B cell lymphoma (DLBCL) uncovered recurrent and highly focal deletions of 22q11.22, including the PRAME gene, which were associated with poor outcome. PRAME-deleted tumors showed cytotoxic T cell immune escape and were associated with cold tumor microenvironments. In addition, PRAME downmodulation was strongly associated with somatic EZH2 Y641 mutations in DLBCL. In turn, PRC2-regulated genes were repressed in isogenic PRAME-KO lymphoma cell lines, and PRAME was found to directly interact with EZH2 as a negative regulator. EZH2 inhibition with EPZ-6438 abrogated these extrinsic and intrinsic effects, leading to PRAME expression and microenvironment restoration in vivo. Our data highlight multiple functions of PRAME during lymphomagenesis and provide a preclinical rationale for synergistic therapies combining epigenetic reprogramming with PRAME-targeted therapies. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Clinical Investigation is the property of American Society for Clinical Investigation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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