血管生成在骨关节炎中的作用机制及治疗启示.

Mechanism and implication of angiogenesis in osteoarthritis.

BACKGROUND: Osteoarthritis is one of the most common degenerative diseases worldwide. Angiogenesis plays an important role in the occurrence and development of osteoarthritis, which is involved in the process of synovitis, cartilage destruction and degeneration, and osteophyte formation. However, the specific mechanism of angiogenesis-mediated osteoarthritis and the regulatory factors affecting angiogenesis have not been determined. OBJECTIVE: To review the pathogenesis of angiogenesis-mediated osteoarthritis, thereby providing reference for future basic research and clinical practice. METHODS: “Osteoarthritis, angiogenesis, angiogenesis inhibitors” were used as the key words in Chinese and English, respectively, for literature retrieval in PubMed and CNKI databases. Retrieval time was from 1980 to 2021. Documents regarding the role and influential factors of angiogenesis in osteoarthritis as well as angiogenesis inhibitors in the treatment of osteoarthritis were collected, including original articles, reviews, dissertations, academic papers, etc. According to the inclusion and exclusion criteria, a total of 74 articles were selected after primary screening and re-screening through reading title, abstract and full-text. RESULTS AND CONCLUSION: Angiogenesis promotes synovitis, cartilage destruction and degeneration, osteophyte formation, and joint pain, which is one of the important factors in the formation and exacerbation of osteoarthritis. The influential factors are angiogenic factors, inflammatory cytokines, interaction between nerves and vessels, exosomes, and non-coding RNAs. Therefore, inhibiting angiogenesis is a potent target for osteoarthritis therapy. Up to date, angiogenesis inhibitors are only confined to vitro experiments and animal models and their clinical application in osteoarthritis should be further discussed. [ABSTRACT FROM AUTHOR]

背景：骨关节炎是全球范围内影响人数最多的退行性疾病之一，而血管生成在骨关节炎的发生发展中占有重要地位，其参与了滑膜炎、软 骨破坏及退化和骨赘形成等过程，但血管生成介导骨关节炎发生的具体机制及影响血管生成的调控因素目前尚无定论。 目的：基于血管生成介导骨关节炎的发病机制进行综述，为今后的基础研究和临床实践提供参考。 方法：中文以“骨关节炎、血管生成、血管生成抑制剂”为检索词，英文以“Osteoarthritis，angiogenesis，angiogenesis inhibitors”为检 索词，利用计算机在PubMed和CNKI数据库中进行检索，检索1980-2021年间，血管生成在骨关节炎中的作用和影响因素以及研究血管生成 抑制剂治疗骨关节炎的相关文献，包括研究原著、综述、学位论文、学术论文等，根据纳入排除标准，通过阅读标题、摘要及全文，经过 初筛和复筛，共筛选出74篇文献。 结果与结论：血管生成在滑膜炎、软骨破坏及退化、关节边缘骨赘形成、关节疼痛中都起着促进作用，是骨关节炎形成和临床症状加剧的重 要因素之一。而促进血管生成的因素主要有促血管生成因子、炎症因子、神经血管相互作用、外泌体及非编码RNA，因此，抑制血管生成成 为骨关节炎治疗的有力靶点，但目前血管抑制剂的研究还局限于体外实验和动物模型，其在骨关节炎的临床应用可行性需进一步探讨。 [ABSTRACT FROM AUTHOR]

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