Invited Review: Long non-coding RNAs: important regulators in the development, function and disorders of the central nervous system.

Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 7609829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2990 (Electronic) Linking ISSN: 03051846 NLM ISO Abbreviation: Neuropathol Appl Neurobiol Subsets: MEDLINE

Original Publication: Oxford, Blackwell Scientific Publications.

Central Nervous System/*metabolism ; Neurodegenerative Diseases/*metabolism ; RNA, Long Noncoding/*metabolism; Central Nervous System/pathology ; Gene Expression Regulation ; Humans ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/pathology ; RNA, Long Noncoding/genetics

Genome-wide transcriptional studies have demonstrated that tens of thousands of long non-coding RNAs (lncRNA) genes are expressed in the central nervous system (CNS) and that they exhibit tissue- and cell-type specificity. Their regulated and dynamic expression and their co-expression with protein-coding gene neighbours have led to the study of the functions of lncRNAs in CNS development and disorders. In this review, we describe the general characteristics, localization and classification of lncRNAs. We also elucidate the examples of the molecular mechanisms of nuclear and cytoplasmic lncRNA actions in the CNS and discuss common experimental approaches used to identify and unveil the functions of lncRNAs. Additionally, we provide examples of lncRNA studies of cell differentiation and CNS disorders including CNS injuries and neurodegenerative diseases. Finally, we review novel lncRNA-based therapies. Overall, this review highlights the important biological roles of lncRNAs in CNS functions and disorders.
(© 2019 British Neuropathological Society.)

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R01 NS088353 United States NS NINDS NIH HHS; R21 EY028647 United States EY NEI NIH HHS; R21 NS113068 United States NS NINDS NIH HHS

Keywords: central nervous system; injuries; lncRNA; molecular mechanisms; neurodegenerative diseases; therapeutic approaches

0 (RNA, Long Noncoding)

Date Created: 20190114 Date Completed: 20200831 Latest Revision: 20231211

20231215

PMC6626588

10.1111/nan.12541

30636336