Evaluation of the efficacy of ivermectin against Theileria orientalis infection in grazing cattle.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101249759 Publication Model: Electronic Cited Medium: Internet ISSN: 1746-6148 (Electronic) Linking ISSN: 17466148 NLM ISO Abbreviation: BMC Vet Res Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central, 2005-
    • Subject Terms:
      Cattle Diseases/*parasitology ; Ivermectin/*pharmacology ; Theileria/*drug effects ; Theileriasis/*drug therapy; Animal Husbandry ; Animals ; Antiparasitic Agents/therapeutic use ; Cattle ; Cattle Diseases/drug therapy ; Phylogeny ; Theileriasis/parasitology
    • Abstract:
      Background: Raising cattle on pastures is known to be beneficial for animal welfare and cost reduction. However, grazing is associated with the risk of contracting tick-borne diseases, such as theileriosis. Here, the efficacy of ivermectin against these diseases and associated clinical symptoms were evaluated.
      Results: A total of 68 cattle from a grazing cattle farm were selected and divided into two groups: the control group (17 cattle) with no preventive treatment and the ivermectin-treated group (51 cattle) in which cattle were treated with pour-on ivermectin prior to grazing. The infection rates of Theileria orientalis and the red blood cell (RBC) profile (e.g., RBC count, hematocrit value, and hemoglobin concentration) were compared in the spring (before grazing) and summer (during grazing) between the two groups. Based on PCR amplification of the major piroplasm surface protein (MPSP) gene, 12 cattle were positive for T. orientalis infection. Phylogenetic analysis revealed that the isolates identified in this study consisted of three MPSP types (1, 2, and 7). The T. orientalis infection rate in the control group during grazing was 3-fold higher than that in the ivermectin-treated group. Moreover, differences in RBC parameters during grazing were greater in the control group than in the ivermectin-treated group. In particular, the hematocrit value was significantly reduced in the control group.
      Conclusions: The results of this study demonstrated that ivermectin had protective effects against T. orientalis infection and RBC hemolysis in grazing cattle.
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    • Grant Information:
      2017R1A2B2005685 National Research Foundation of Korea; 1116043-1 Ministry of Agriculture, Food and Rural Affairs
    • Contributed Indexing:
      Keywords: Grazing; Hematocrit; Ivermectin; Theileria orientalis
    • Accession Number:
      0 (Antiparasitic Agents)
      70288-86-7 (Ivermectin)
    • Publication Date:
      Date Created: 20190818 Date Completed: 20200106 Latest Revision: 20200225
    • Publication Date:
      20231215
    • Accession Number:
      PMC6697941
    • Accession Number:
      10.1186/s12917-019-2042-2
    • Accession Number:
      31420047