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An Investigation of the Impacts of Three Anesthetic Regimens on Task-Functional Magnetic Resonance Imaging and Functional Connectivity Resting-State Functional Magnetic Resonance Imaging in Sprague Dawley and Wistar Rats.
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- Author(s): Lu CQ;Lu CQ; Zeng CH; Zeng CH; Cui Y; Cui Y; Meng XP; Meng XP; Luan Y; Luan Y; Xu XM; Xu XM; Ju S; Ju S
- Source:
Brain connectivity [Brain Connect] 2022 Feb; Vol. 12 (1), pp. 74-84. Date of Electronic Publication: 2021 Jun 15.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101550313 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2158-0022 (Electronic) Linking ISSN: 21580014 NLM ISO Abbreviation: Brain Connect Subsets: MEDLINE
- Publication Information: Original Publication: New Rochelle, NY : Mary Ann Liebert, Inc.
- Subject Terms:
- Abstract: Aim: The aim of this study was to investigate basic task-functional magnetic resonance imaging (fMRI) or resting-state fMRI (rs-fMRI) results on Sprague Dawley (SD) rats and Wistar rats under three anesthetic regimens. Introduction: SD rats and Wistar rats are the two-most commonly used rat strains in medical research and neuroimaging studies. It still lacks a direct comparison of basic task-fMRI and rs-fMRI results between the Wistar rats and SD rats under different anesthetic regimens. Methods: Two rat strains and different time points were adopted to investigate task-fMRI activation and rs-fMRI functional connectivity (FC) results under three kinds of anesthetic regimens (2-2.5% isoflurane only, dexmedetomidine bolus combined with a continuous infusion, and dexmedetomidine bolus combined with 0.3-0.5% isoflurane). The electrical forepaw stimulation method and seed-based FC results were used to compare the task-fMRI brain activation and rs-fMRI FC patterns between the two rat strains. Results: The results showed that Wistar rats had more robust brain activation in task fMRI experiments while exhibiting a less specific interhemispheric FC than that of SD rats under the two dexmedetomidine anesthetic regimens. Moreover, even low-level isoflurane could significantly affect task-fMRI and rs-fMRI results in both rat strains. Conclusions: SD and Wistar rats showed different brain activations and interhemispheric FC patterns under the two dexmedetomidine anesthetic regimens. These results may serve as reference information for small-animal fMRI studies. Impact statement Our study demonstrates different stimulation-induced blood oxygen level-dependent responses and functional connectivity patterns between Sprague Dawley rats and Wistar rats under three anesthetics. This study provides some reference results for different anesthetics' effects on different rat strains in different functional magnetic resonance imaging modalities.
- Contributed Indexing: Keywords: anesthesia; functional connectivity; isoflurane; medetomidine; rat strain
- Accession Number: 0 (Anesthetics)
67VB76HONO (Dexmedetomidine)
CYS9AKD70P (Isoflurane) - Publication Date: Date Created: 20210505 Date Completed: 20220503 Latest Revision: 20220503
- Publication Date: 20231215
- Accession Number: 10.1089/brain.2020.0875
- Accession Number: 33947271
- Source:
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