Morphological and functional brain changes in chronic cancer-related pain: A systematic review.

Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101292775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-8494 (Electronic) Linking ISSN: 19328486 NLM ISO Abbreviation: Anat Rec (Hoboken) Subsets: MEDLINE

Original Publication: Hoboken, NJ : John Wiley & Sons, 2007-

Brain*/diagnostic imaging ; Cancer Pain*/diagnostic imaging ; Chronic Pain*/diagnostic imaging ; Chronic Pain*/etiology ; Neoplasms*/complications; Humans ; Positron Emission Tomography Computed Tomography

The purpose of this study was to perform a systematic review of the available literature on morphological and functional brain changes measured by modern neuroimaging techniques in patients suffering from chronic cancer-related pain. A systematic search was conducted in PubMed, Embase, and Web of Science using different keyword combinations. In addition, a hand search was performed on the reference lists and several databases to retrieve supplementary primary studies. Eligible articles were assessed for methodological quality and risk of bias and reviewed by two independent researchers. The search yielded only four studies, three of which used MRI and one PET-CT. None of the studies measured longitudinal morphological (i.e., gray or white matter) changes. All studies investigated functional brain changes and found differences in specific brain regions and networks between patients with chronic cancer-related pain and pain-free cancer patients or healthy volunteers. Some of these alterations were found in brain networks that also show changes in non-cancer populations with chronic pain (e.g., the default mode network and salience network). However, specific findings were inconsistent, and there was substantial variation in imaging methodology, analysis, sample size, and study quality. There is a striking lack of research on morphological brain changes in patients with chronic cancer-related pain. Moreover, only a few studies investigated functional brain changes. In the retrieved studies, there is some evidence that alterations occur in brain networks also involved in other chronic non-cancer pain syndromes. However, the low sample sizes of the studies, finding inconsistencies, and methodological heterogeneity do not allow for robust conclusions.
(© 2022 American Association for Anatomy.)

Androulakis, X. M., Krebs, K., Peterlin, B. L., Zhang, T., Maleki, N., Sen, S., Rorden, C., & Herath, P. (2017). Modulation of intrinsic resting-state fMRI networks in women with chronic migraine. Neurology, 89(2), 163-169.
Apkarian, A. V., Hashmi, J. A., & Baliki, M. N. (2011). Pain and the brain: Specificity and plasticity of the brain in clinical chronic pain. Pain, 152(3 Suppl), S49-S64.
Apkarian, A. V., Sosa, Y., Sonty, S., Levy, R. M., Harden, R. N., Parrish, T. B., & Gitelman, D. R. (2004). Chronic back pain is associated with decreased prefrontal and thalamic gray matter density. The Journal of Neuroscience, 24(46), 10410-10415.
Ashburner, J., & Friston, K. J. (2000). Voxel-based morphometry--The methods. NeuroImage, 11(6 Pt 1), 805-821.
Baliki, M. N., Chialvo, D. R., Geha, P. Y., Levy, R. M., Harden, R. N., Parrish, T. B., & Apkarian, A. V. (2006). Chronic pain and the emotional brain: Specific brain activity associated with spontaneous fluctuations of intensity of chronic back pain. The Journal of Neuroscience, 26(47), 12165-12173.
Baliki, M. N., Mansour, A. R., Baria, A. T., & Apkarian, A. V. (2014). Functional reorganization of the default mode network across chronic pain conditions. PLoS One, 9(9), e106133.
Baliki, M. N., Petre, B., Torbey, S., Herrmann, K. M., Huang, L., Schnitzer, T. J., Fields, H. L., & Apkarian, A. V. (2012). Corticostriatal functional connectivity predicts transition to chronic back pain. Nature Neuroscience, 15(8), 1117-1119.
Baliki, M. N., Schnitzer, T. J., Bauer, W. R., & Apkarian, A. V. (2011). Brain morphological signatures for chronic pain. PLoS One, 6(10), e26010.
Barad, M. J., Ueno, T., Younger, J., Chatterjee, N., & Mackey, S. (2014). Complex regional pain syndrome is associated with structural abnormalities in pain-related regions of the human brain. The Journal of Pain, 15(2), 197-203.
Barroso, J., Wakaizumi, K., Reis, A. M., Baliki, M., Schnitzer, T. J., Galhardo, V., & Apkarian, A. V. (2021). Reorganization of functional brain network architecture in chronic osteoarthritis pain. Human Brain Mapping, 42(4), 1206-1222.
Bennett, M. I., Kaasa, S., Barke, A., Korwisi, B., Rief, W., & Treede, R. D. (2019). The IASP classification of chronic pain for ICD-11: Chronic cancer-related pain. Pain, 160(1), 38-44.
Bennett, M. I., Rayment, C., Hjermstad, M., Aass, N., Caraceni, A., & Kaasa, S. (2012). Prevalence and aetiology of neuropathic pain in cancer patients: A systematic review. Pain, 153(2), 359-365.
Boissoneault, J., Penza, C. W., George, S. Z., Robinson, M. E., & Bishop, M. D. (2020). Comparison of brain structure between pain-susceptible and asymptomatic individuals following experimental induction of low back pain. The Spine Journal, 20(2), 292-299.
Boland, E. G., Selvarajah, D., Hunter, M., Ezaydi, Y., Tesfaye, S., Ahmedzai, S. H., Snowden, J. A., & Wilkinson, I. D. (2014). Central pain processing in chronic chemotherapy-induced peripheral neuropathy: A functional magnetic resonance imaging study. PLoS One, 9(5), e96474.
Brown, M., & Farquhar-Smith, P. (2017). Pain in cancer survivors; filling in the gaps. British Journal of Anaesthesia., 119(4), 723-736.
Bruce, J., Thornton, A. J., Powell, R., Johnston, M., Wells, M., Heys, S. D., Thompson, A. M., Smith, C. W., Chambers, A. W., Scott, N. W., & Recovery Study Group. (2014). Psychological, surgical, and sociodemographic predictors of pain outcomes after breast cancer surgery: A population-based cohort study. Pain, 155(2), 232-243.
Buckner, R. L., Andrews-Hanna, J. R., & Schacter, D. L. (2008). The brain's default network. Annals of the New York Academy of Sciences., 1124(1), 1-38.
Buehlmann, D., Grandjean, J., Xandry, J., & Rudin, M. (2018). Longitudinal resting-state functional magnetic resonance imaging in a mouse model of metastatic bone cancer reveals distinct functional reorganizations along a developing chronic pain state. Pain, 159(4), 719-727.
Buehlmann, D., Ielacqua, G. D., Xandry, J., & Rudin, M. (2019). Prospective administration of anti-nerve growth factor treatment effectively suppresses functional connectivity alterations after cancer-induced bone pain in mice. Pain, 160(1), 151-159.
Bukkieva, T., Pospelova, M., Efimtsev, A., Fionik, O., Alekseeva, T., Samochernych, K., Gorbunova, E., Krasnikova, V., Makhanova, A., Levchuk, A., Trufanov, G., Combs, S., & Shevtsov, M. (2022). Functional network connectivity reveals the brain functional alterations in breast cancer survivors. Journal of Clinical Medicine, 11(3), 617.
Burgmer, M., Gaubitz, M., Konrad, C., Wrenger, M., Hilgart, S., Heuft, G., & Pfleiderer, B. (2009). Decreased gray matter volumes in the cingulo-frontal cortex and the amygdala in patients with fibromyalgia. Psychosomatic Medicine, 71(5), 566-573.
Buvanendran, A., Ali, A., Stoub, T. R., Kroin, J. S., & Tuman, K. J. (2010). Brain activity associated with chronic cancer pain. Pain Physician, 13(5), E337-E342.
Cauda, F., Palermo, S., Costa, T., Torta, R., Duca, S., Vercelli, U., Geminiani, G., & Torta, D. M. E. (2014). Gray matter alterations in chronic pain: A network-oriented meta-analytic approach. NeuroImage: Clinical, 4, 676-686.
Cavanna, A. E., & Trimble, M. R. (2006). The precuneus: A review of its functional anatomy and behavioural correlates. Brain, 129(3), 564-583.
Centers for Disease Control and Prevention (CDC). (2011). Cancer survivors--United States, 2007. MMWR. Morbidity and Mortality Weekly Report, 60(9), 269-272.
Chen, X., Spaeth, R. B., Retzepi, K., Ott, D., & Kong, J. (2014). Acupuncture modulates cortical thickness and functional connectivity in knee osteoarthritis patients. Scientific Reports, 4, 6482.
Coppieters, I., Meeus, M., Kregel, J., Caeyenberghs, K., De Pauw, R., Goubert, D., & Cagnie, B. (2016). Relations between brain alterations and clinical pain measures in chronic musculoskeletal pain: A systematic review. The Journal of Pain, 17(9), 949-962.
Cruccu, G., Garcia-Larrea, L., Hansson, P., Keindl, M., Lefaucheur, J. P., Paulus, W., Taylor, R., Tronnier, V., Truini, A., & Attal, N. (2016). EAN guidelines on central neurostimulation therapy in chronic pain conditions. European Journal of Neurology, 23(10), 1489-1499.
Draganski, B., Moser, T., Lummel, N., Gänssbauer, S., Bogdahn, U., Haas, F., & May, A. (2006). Decrease of thalamic gray matter following limb amputation. NeuroImage, 31(3), 951-957.
Erpelding, N., Simons, L., Lebel, A., Serrano, P., Pielech, M., Prabhu, S., Becerra, L., & Borsook, D. (2016). Rapid treatment-induced brain changes in pediatric CRPS. Brain Structure & Function, 221(2), 1095-1111.
Etkin, A., Egner, T., & Kalisch, R. (2011). Emotional processing in anterior cingulate and medial prefrontal cortex. Trends in Cognitive Sciences, 15(2), 85-93.
Falk, S., & Dickenson, A. H. (2014). Pain and nociception: Mechanisms of cancer-induced bone pain. Journal of Clinical Oncology, 32(16), 1647-1654.
Fathers, E., Thrush, D., Huson, S. M., & Norman, A. (2002). Radiation-induced brachial plexopathy in women treated for carcinoma of the breast. Clinical Rehabilitation, 16(2), 160-165.
Fitzcharles, M. A., Cohen, S. P., Clauw, D. J., Littlejohn, G., Usui, C., & Häuser, W. (2021). Nociplastic pain: Towards an understanding of prevalent pain conditions. Lancet, 397(10289), 2098-2110.
Gallaway, M. S., Townsend, J. S., Shelby, D., & Puckett, M. C. (2020). Pain among cancer survivors. Preventing Chronic Disease, 17, E54.
Greco, M. T., Roberto, A., Corli, O., Deandrea, S., Bandieri, E., Cavuto, S., & Apolone, G. (2014). Quality of cancer pain management: An update of a systematic review of undertreatment of patients with cancer. Journal of Clinical Oncology, 32(36), 4149-4154.
Grosen, K., Laue Petersen, G., Pfeiffer-Jensen, M., Hoejsgaard, A., & Pilegaard, H. K. (2013). Persistent post-surgical pain following anterior thoracotomy for lung cancer: A cross-sectional study of prevalence, characteristics and interference with functioning. European Journal of Cardio-Thoracic Surgery, 43(1), 95-103.
Gungor, N. Z., & Johansen, J. (2019). A chronic pain in the ACC. Neuron, 102(5), 903-905.
Gustin, S. M., Peck, C. C., Cheney, L. B., Macey, P. M., Murray, G. M., & Henderson, L. A. (2012). Pain and plasticity: Is chronic pain always associated with somatosensory cortex activity and reorganization? The Journal of Neuroscience, 32(43), 14874-14884.
Gustin, S. M., Peck, C. C., Wilcox, S. L., Nash, P. G., Murray, G. M., & Henderson, L. A. (2011). Different pain, different brain: Thalamic anatomy in neuropathic and non-neuropathic chronic pain syndromes. The Journal of Neuroscience, 31(16), 5956-5964.
Gustin, S. M., Wrigley, P. J., Siddall, P. J., & Henderson, L. A. (2010). Brain anatomy changes associated with persistent neuropathic pain following spinal cord injury. Cerebral Cortex, 20(6), 1409-1419.
Harrington, C. B., Hansen, J. A., Moskowitz, M., Todd, B. L., & Feuerstein, M. (2010). It's not over when it's over: Long-term symptoms in cancer survivors--a systematic review. International Journal of Psychiatry in Medicine, 40(2), 163-181.
Hashmi, J. A., Baliki, M. N., Huang, L., Baria, A. T., Torbey, S., Hermann, K. M., Schnitzer, T. J., & Apkarian, A. V. (2013). Shape shifting pain: Chronification of back pain shifts brain representation from nociceptive to emotional circuits. Brain, 136(Pt 9), 2751-2768.
Hiraga, S.-I., Itokazu, T., Nishibe, M., & Yamashita, T. (2022). Neuroplasticity related to chronic pain and its modulation by microglia. Inflammation and Regeneration, 42(1), 15.
Hubbard, C. S., Khan, S. A., Keaser, M. L., Mathur, V. A., Goyal, M., & Seminowicz, D. A. (2014). Altered brain structure and function correlate with disease severity and pain catastrophizing in migraine patients. eNeuro., 1(1), e20.14.
Ivo, R., Nicklas, A., Dargel, J., Sobottke, R., Delank, K. S., Eysel, P., & Weber, B. (2013). Brain structural and psychometric alterations in chronic low back pain. European Spine Journal, 22(9), 1958-1964.
Jahn, P., Deak, B., Mayr, A., Stankewitz, A., Keeser, D., Griffanti, L., Witkovsky, V., Irving, S., & Schulz, E. (2021). Intrinsic network activity reflects the ongoing experience of chronic pain. Scientific Reports, 11(1), 21870.
Jefferson, T., Kelly, C. J., & Martina, M. (2021). Differential rearrangement of excitatory inputs to the medial prefrontal cortex in chronic pain models. Frontiers in Neural Circuits., 791043, 15.
Jensen, M. P., Chang, H. Y., Lai, Y. H., Syrjala, K. L., Fann, J. R., & Gralow, J. R. (2010). Pain in long-term breast cancer survivors: Frequency, severity, and impact. Pain Medicine, 11(7), 1099-1106.
Jia, Z., & Yu, S. (2017). Grey matter alterations in migraine: A systematic review and meta-analysis. NeuroImage Clinical, 14, 130-140.
Jiang, Y., Oathes, D., Hush, J., Darnall, B., Charvat, M., Mackey, S., & Etkin, A. (2016). Perturbed connectivity of the amygdala and its subregions with the central executive and default mode networks in chronic pain. Pain, 157(9), 1970-1978.
Kang, D., McAuley, J. H., Kassem, M. S., Gatt, J. M., & Gustin, S. M. (2019). What does the grey matter decrease in the medial prefrontal cortex reflect in people with chronic pain? European Journal of Pain, 23(2), 203-219.
Kong, J., Spaeth, R. B., Wey, H.-Y., Cheetham, A., Cook, A. H., Jensen, K., Tan, Y., Liu, H., Wang, D., Loggia, M., Napadow, V., Smoller, J., Wasan, A., & Gollub, R. (2013). S1 is associated with chronic low back pain: A functional and structural MRI study. Molecular Pain, 9, 43.
Kuchinad, A., Schweinhardt, P., Seminowicz, D. A., Wood, P. B., Chizh, B. A., & Bushnell, M. C. (2007). Accelerated brain gray matter loss in fibromyalgia patients: Premature aging of the brain? The Journal of Neuroscience, 27(15), 4004-4007.
Lee, M. H., Smyser, C. D., & Shimony, J. S. (2013). Resting-state fMRI: A review of methods and clinical applications. AJNR American Journal of Neuroradiology., 34(10), 1866-1872.
Levy, M. H., Chwistek, M., & Mehta, R. S. (2008). Management of chronic pain in cancer survivors. Cancer Journal, 14(6), 401-409.
Li, W., Qin, W., Liu, H., Fan, L., Wang, J., Jiang, T., & Yu, C. (2013). Subregions of the human superior frontal gyrus and their connections. NeuroImage, 78, 46-58.
Logothetis, N. K., Pauls, J., Augath, M., Trinath, T., & Oeltermann, A. (2001). Neurophysiological investigation of the basis of the fMRI signal. Nature, 412(6843), 150-157.
Luchtmann, M., Steinecke, Y., Baecke, S., Lutzkendorf, R., Bernarding, J., Kohl, J., Jöllenbeck, B., Tempelmann, C., Ragert, P., & Firsching, R. (2014). Structural brain alterations in patients with lumbar disc herniation: A preliminary study. PLoS One, 9(3), e90816.
Mansour, A. R., Farmer, M. A., Baliki, M. N., & Apkarian, A. V. (2014). Chronic pain: The role of learning and brain plasticity. Restorative Neurology and Neuroscience, 32(1), 129-139.
Mao, C. P., Yang, H. J., Yang, Q. X., Sun, H. H., Zhang, G. R., & Zhang, Q. J. (2022). Altered amygdala-prefrontal connectivity in chronic nonspecific low Back pain: Resting-state fMRI and dynamic causal modelling study. Neuroscience, 482, 18-29.
May, A. (2008). Chronic pain may change the structure of the brain. Pain, 137(1), 7-15.
Metz, A. E., Yau, H. J., Centeno, M. V., Apkarian, A. V., & Martina, M. (2009). Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain. Proceedings of the National Academy of Sciences of the United States of America, 106(7), 2423-2428.
Newman, E., Moulton, E., Becerra, L., & Borsook, D. (2014). Chapter 2 - morphological brain changes in chronic pain: Mystery and meaning. In C. Y. Saab (Ed.), Chronic pain and brain abnormalities (pp. 15-40). Academic Press.
Nicholas, M., Vlaeyen, J. W. S., Rief, W., Barke, A., Aziz, Q., Benoliel, R., Cohen, M., Evers, S., Giamberardino, M. A., Goebel, A., Korwisi, B., Perrot, S., Svensson, P., Wang, S. J., Treede, R. D., & The IASP Taskforce for the Classification of Chronic Pain. (2019). The IASP classification of chronic pain for ICD-11: Chronic primary pain. Pain, 160(1), 28-37.
Niscola, P., Romani, C., Scaramucci, L., Dentamaro, T., Cupelli, L., Tendas, A., Piccioni, D., Giovannini, M., Tolu, B., Cartoni, C., Arcuri, E., Perrotti, A., Palumbo, R., & de Fabritiis, P. (2008). Pain syndromes in the setting of haematopoietic stem cell transplantation for haematological malignancies. Bone Marrow Transplantation, 41(9), 757-764.
Nudelman, K. N., McDonald, B. C., Wang, Y., Smith, D. J., West, J. D., O'Neill, D. P., Zanville, N., Champion, V., Schneider, B., & Saykin, A. (2016). Cerebral perfusion and gray matter changes associated with chemotherapy-induced peripheral neuropathy. Journal of Clinical Oncology, 34(7), 677-683.
Obermann, M., Rodriguez-Raecke, R., Naegel, S., Holle, D., Mueller, D., Yoon, M. S., Theysohn, N., Blex, S., Diener, H. C., & Katsarava, Z. (2013). Gray matter volume reduction reflects chronic pain in trigeminal neuralgia. NeuroImage, 74, 352-358.
Ogawa, S., & Lee, T. M. (1990). Magnetic resonance imaging of blood vessels at high fields: in vivo and in vitro measurements and image simulation. Magnetic Resonance in Medicine, 16(1), 9-18.
Ogawa, S., Lee, T.-M., Nayak, A. S., & Glynn, P. (1990). Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magnetic Resonance in Medicine, 14(1), 68-78.
Ong, W.-Y., Stohler, C. S., & Herr, D. R. (2019). Role of the prefrontal cortex in pain processing. Molecular Neurobiology, 56(2), 1137-1166.
Pachman, D. R., Barton, D. L., Swetz, K. M., & Loprinzi, C. L. (2012). Troublesome symptoms in cancer survivors: Fatigue, insomnia, neuropathy, and pain. Journal of Clinical Oncology, 30(30), 3687-3696.
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J., Akl, E., Brennan, S., Chou, R., Glanville, J. M., Grimshaw, J., Hrõbjartsson, A., Lalu, M., Li, T., Loder, E., Mayo-Wilson, E., … Moher, D. (2021a). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ, 372, n71.
Page, M. J., McKenzie. J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow C D et al. (2021b) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ., 372(n71). doi:10.1136/bmj.n71.
Pan, P. L., Zhong, J. G., Shang, H. F., Zhu, Y. L., Xiao, P. R., Dai, Z. Y., & Shi, H. C. (2015). Quantitative meta-analysis of grey matter anomalies in neuropathic pain. European Journal of Pain, 19(9), 1224-1231.
Pomares, F. B., Funck, T., Feier, N. A., Roy, S., Daigle-Martel, A., Ceko, M., Narayanan, S., Araujo, D., Thiel, A., Stikov, N., Fitzcharles, M. A., & Schweinhardt, P. (2017). Histological underpinnings of Grey matter changes in fibromyalgia investigated using multimodal brain imaging. The Journal of Neuroscience, 37(5), 1090-1101.
Raichle, M. E. (2015). The brain's default mode network. Annual Review of Neuroscience, 38, 433-447.
Richardson, W. S., Wilson, M. C., Nishikawa, J., & Hayward, R. S. (1995). The well-built clinical question: A key to evidence-based decisions. ACP Journal Club, 123(3), A12-A13.
Rocca, M. A., Ceccarelli, A., Falini, A., Colombo, B., Tortorella, P., Bernasconi, L., Comi, G., Scotti, G., & Filippi, M. (2006). Brain gray matter changes in migraine patients with T2-visible lesions: A 3-T MRI study. Stroke, 37(7), 1765-1770.
Rodriguez-Raecke, R., Niemeier, A., Ihle, K., Ruether, W., & May, A. (2009). Brain gray matter decrease in chronic pain is the consequence and not the cause of pain. The Journal of Neuroscience, 29(44), 13746-13750.
Schmidt-Wilcke, T., Leinisch, E., Straube, A., Kämpfe, N., Draganski, B., Diener, H. C., Bogdahn, U., & May, A. (2005). Gray matter decrease in patients with chronic tension type headache. Neurology, 65(9), 1483-1486.
Schmidt-Wilcke, T., Luerding, R., Weigand, T., Jürgens, T., Schuierer, G., Leinisch, E., & Bogdahn, U. (2007). Striatal grey matter increase in patients suffering from fibromyalgia--a voxel-based morphometry study. Pain, 132(Suppl 1), 109-116.
Sellmeijer, J., Mathis, V., Hugel, S., Li, X. H., Song, Q., Chen, Q. Y., Barthas, F., Lutz, P. E., Karatas, M., Luthi, A., Veinante, P., Aertsen, A., Barrot, M., Zhuo, M., & Yalcin, I. (2018). Hyperactivity of anterior cingulate cortex areas 24a/24b drives chronic pain-induced anxiodepressive-like consequences. The Journal of Neuroscience, 38(12), 3102-3115.
Seminowicz, D. A., & Moayedi, M. (2017). The dorsolateral prefrontal cortex in acute and chronic pain. The Journal of Pain, 18(9), 1027-1035.
Seminowicz, D. A., Shpaner, M., Keaser, M. L., Krauthamer, G. M., Mantegna, J., Dumas, J. A., Newhouse, P. A., Filippi, C. G., Keefe, F. J., & Naylor, M. R. (2013). Cognitive-behavioral therapy increases prefrontal cortex gray matter in patients with chronic pain. The Journal of Pain, 14(12), 1573-1584.
Seretny, M., Currie, G. L., Sena, E. S., Ramnarine, S., Grant, R., MacLeod, M. R., Colvin, L. A., & Fallon, M. (2014). Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. Pain, 155(12), 2461-2470.
Smallwood, R. F., Laird, A. R., Ramage, A. E., Parkinson, A. L., Lewis, J., Clauw, D. J., Williams, D. A., Schmidt-Wilcke, T., Farrell, M. J., Eickhoff, S. B., & Robin, D. A. (2013). Structural brain anomalies and chronic pain: A quantitative meta-analysis of gray matter volume. The Journal of Pain, 14(7), 663-675.
Smith, A. M., Leeming, A., Fang, Z., Hatchard, T., Mioduszewski, O., Schneider, M. A., Ferdossifard, A., Shergill, Y., Khoo, E. L., & Poulin, P. (2021). Mindfulness-based stress reduction alters brain activity for breast cancer survivors with chronic neuropathic pain: Preliminary evidence from resting-state fMRI. Journal of Cancer Survivorship, 15(4), 518-525.
Tatu, K., Costa, T., Nani, A., Diano, M., Quarta, D. G., Duca, S., Apkarian, A. V., Fox, P. T., & Cauda, F. (2018). How do morphological alterations caused by chronic pain distribute across the brain? A meta-analytic co-alteration study. NeuroImage: Clinical, 18, 15-30.
Tu, Y., Cao, J., Bi, Y., & Hu, L. (2021). Magnetic resonance imaging for chronic pain: Diagnosis, manipulation, and biomarkers. Science China. Life Sciences, 64(6), 879-896.
Ung, H., Brown, J. E., Johnson, K. A., Younger, J., Hush, J., & Mackey, S. (2014). Multivariate classification of structural MRI data detects chronic low Back pain. Cerebral Cortex, 24(4), 1037-1044.
Utevsky, A. V., Smith, D. V., & Huettel, S. A. (2014). Precuneus is a functional Core of the default-mode network. The Journal of Neuroscience, 34(3), 932-940.
Vachon-Presseau, E., Centeno, M. V., Ren, W., Berger, S. E., Tetreault, P., Ghantous, M., Baria, A., Farmer, M., Baliki, M., Schnitzer, T., & Apkarian, A. (2016). The emotional brain as a predictor and amplifier of chronic pain. Journal of Dental Research, 95(6), 605-612.
Vachon-Presseau, E., Tetreault, P., Petre, B., Huang, L., Berger, S. E., Torbey, S., Baria, A., Mansour, A., Hashmi, J., Griffith, J., Comasco, E., Schnitzer, T., Baliki, M., & Apkarian, A. (2016). Corticolimbic anatomical characteristics predetermine risk for chronic pain. Brain, 139(Pt 7), 1958-1970.
van den Beuken-van Everdingen, M. H. J., de Rijke, J. M., Kessels, A. G., Schouten, H. C., van Kleef, M., & Patijn, J. (2007). High prevalence of pain in patients with cancer in a large population-based study in The Netherlands. Pain, 132(3), 312-320.
van Ettinger-Veenstra, H., Lundberg, P., Alföldi, P., Södermark, M., Graven-Nielsen, T., Sjörs, A., Engström, M., & Gerdle, B. (2019). Chronic widespread pain patients show disrupted cortical connectivity in default mode and salience networks, modulated by pain sensitivity. Journal of Pain Research, 12, 1743-1755.
Williams, J. A., Burgess, S., Suckling, J., Lalousis, P. A., Batool, F., Griffiths, S. L., Palmer, E., Karwath, A., Barsky, A., Gkoutos, G. V., Wood, S., Barnes, N. M., David, A. S., Donohoe, G., Neill, J. C., Deakin, B., Khandaker, G. M., Upthegrove, R., PIMS Collaboration, … Harrison, N. (2022). Inflammation and brain structure in schizophrenia and other neuropsychiatric disorders: A Mendelian randomization study. JAMA Psychiatry., 79(5), 498-507.
Yarns, B. C., Cassidy, J. T., & Jimenez, A. M. (2022). At the intersection of anger, chronic pain, and the brain: A mini-review. Neuroscience & Biobehavioral Reviews., 135, 104558.
Youssef, A. M., Peng, K., Kim, P. K., Lebel, A., Sethna, N. F., Kronman, C., Zurakowski, D., Borsook, D., & Simons, L. E. (2021). Pain stickiness in pediatric complex regional pain syndrome: A role for the nucleus accumbens. Neurobiol Pain., 9, 100062.
Zhang, Z., Gewandter, J. S., & Geha, P. (2022). Brain imaging biomarkers for chronic pain. Frontiers in Neurology, 12, 734821.

G042221N Fonds Wetenschappelijk Onderzoek

Keywords: chronic cancer-related pain; fMRI; neuroimaging

Date Created: 20221107 Date Completed: 20240119 Latest Revision: 20240411

20240411

10.1002/ar.25113

36342941