X-chromosomal STRs in aDNA kinship analysis.

Publisher: E Schweizerbartsche Country of Publication: Germany NLM ID: 0372377 Publication Model: Print Cited Medium: Print ISSN: 0003-5548 (Print) Linking ISSN: 00035548 NLM ISO Abbreviation: Anthropol Anz Subsets: MEDLINE

Original Publication: Stuttgart : E Schweizerbartsche

DNA, Ancient* ; DNA, Mitochondrial*/genetics; Humans ; Haplotypes/genetics ; Germany ; Body Remains ; Microsatellite Repeats/genetics ; Chromosomes, Human, Y/genetics

The analysis of ancient DNA (aDNA) from human skeletal remains can provide useful insights when investigating archaeological finds. One popular application of aDNA is to examine genealogical relationships between individuals recovered at the same archaeological site. For the reconstruction of genealogical relationships, several genetic markers are commonly used: autosomal STRs, mitochondrial lineages (based on SNP-analysis) and Y-chromosomal haplotypes (based on Y-STR-analysis). In this paper, we present the additional opportunities that X-STRs provide in aDNA kinship reconstruction, especially in deficiency cases and for the examination of father-daughter relationships. Possible applications are demonstrated on a range of different kinship reconstructions: confirmation of half-siblingship in the Lichtenstein cave (Germany), exclusion of two potential father-daughter relationships in Goslar (Germany), investigation of three siblingships in Boilstädt (Germany) as well as the confirmation of a father-daughter relationship in Stolpe (Germany). This study shows that the analysis of X-STRs can contribute to the investigation of relationship constellations otherwise difficult to approach (e.g. father-daughter relationships) and that X-STRs are useful to support and complement autosomal STRs, mtDNA and Y-STR data.

0 (DNA, Ancient)
0 (DNA, Mitochondrial)

Date Created: 20230815 Date Completed: 20240306 Latest Revision: 20240306

20240306

10.1127/anthranz/2023/1714

37580949