Shared sequence characteristics identified in non-canonical rearrangements of HSV-1 genomes.

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  • Additional Information
    • Source:
      Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE
    • Publication Information:
      Publication: Washington Dc : American Society For Microbiology
      Original Publication: Baltimore, American Society for Microbiology.
    • Subject Terms:
      DNA, Viral*/genetics ; Genome, Viral*/genetics ; Herpesvirus 1, Human*/genetics ; Herpesvirus 1, Human*/growth & development ; Mutation*; Virus Replication ; Eukaryotic Cells/virology ; Cell Nucleus/virology ; Serial Passage ; Humans
    • Abstract:
      Importance: Mutations and genetic rearrangements are the primary driving forces of evolution. Viruses provide valuable model systems for investigating these mechanisms due to their rapid evolutionary rates and vast genetic variability. To investigate genetic rearrangements in the double-stranded DNA genome of herpes simplex virus type 1, the viral population was serially passaged in various cell types. The serial passaging led to formation of defective genomes, resulted from cell-specific non-canonical rearrangements (NCRs). Interestingly, we discovered shared sequence characteristics underlying the formation of these NCRs across all cell types. Moreover, most NCRs identified in clinical samples shared these characteristics. Based on our findings, we propose a model elucidating the formation of NCRs during viral replication within the nucleus of eukaryotic cells.
      Competing Interests: The authors declare no conflict of interest.
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    • Grant Information:
      Grant 1816/21 Israel Science Foundation (ISF); Grant 2019331 United States - Israel Binational Science Foundation (BSF)
    • Contributed Indexing:
      Keywords: DNA rearrangements; defective interfering particles; herpesviruses; microhomology
    • Accession Number:
      0 (DNA, Viral)
    • Publication Date:
      Date Created: 20231122 Date Completed: 20240103 Latest Revision: 20240103
    • Publication Date:
      20240103
    • Accession Number:
      PMC10734421
    • Accession Number:
      10.1128/jvi.00955-23
    • Accession Number:
      37991369