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Metabolic and functional responses of immature and mature rabbit hearts to hypoperfusion, ischemia, and reperfusion.
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- Author(s): Matherne GP;Matherne GP; Headrick JP; Berr S; Berne RM
- Source:
The American journal of physiology [Am J Physiol] 1993 Jun; Vol. 264 (6 Pt 2), pp. H2141-53.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.- Language:
English - Source:
- Additional Information
- Source: Publisher: American Physiological Society Country of Publication: United States NLM ID: 0370511 Publication Model: Print Cited Medium: Print ISSN: 0002-9513 (Print) Linking ISSN: 00029513 NLM ISO Abbreviation: Am J Physiol Subsets: MEDLINE
- Publication Information: Publication: Bethesda, MD : American Physiological Society
Original Publication: Washington [etc.] American Physiological Society. - Subject Terms: Myocardial Reperfusion*; Aging/*metabolism ; Aging/*physiology ; Coronary Disease/*metabolism ; Coronary Disease/*physiopathology ; Heart/*physiopathology ; Myocardial Ischemia/*metabolism ; Myocardial Ischemia/*physiopathology; Animals ; Hemodynamics ; In Vitro Techniques ; Purines/blood ; Rabbits ; Veins ; Ventricular Function
- Abstract: Relationships between contractile function and cytosolic metabolism were examined in mature and immature rabbit hearts during graded hypoperfusion, global ischemia, and reperfusion. Differences in basal contractile function and metabolic demand in immature and mature hearts were paralleled by differences in energy substrate indexed by the phosphorylation potential and phosphocreatine (PCr) levels but not by differences in ATP, pH, or inorganic phosphate (Pi). During graded hypoperfusion, contractility declined comparably in both age groups. Relative changes in [ATP], [PCr], and [Pi] were similar in both groups, whereas pH declined to a greater extent in mature hearts, and [Mg2+] declined to a greater extent in immature hearts. Contractile function correlated most consistently with [Pi] and supports the notion that Pi (and H+) are primary determinants of function in underperfused immature and mature hearts. Aerobic efficiency declined in immature but not mature hearts during hypoperfusion, reflecting an improved ratio of ATP formation relative to ATP hydrolysis in the hypoperfused immature myocardium. Finally, the enhanced contractile recovery from global ischemia in immature compared with mature hearts (to 93 +/- 4 vs. 79 +/- 2% of basal function) was unrelated to recovery of ATP, Pi, pH, Mg2+, [ATP]/[ADP].[Pi], or free-energy change of ATP hydrolysis. Age-related differences in maintenance of ATP may be related to enhanced metabolic activation of glycolysis coupled with better buffering of pH and an improved match between ATP hydrolysis and ATP formation in immature heart.
- Grant Information: HL-02457 United States HL NHLBI NIH HHS; HL-10384 United States HL NHLBI NIH HHS
- Accession Number: 0 (Purines)
- Publication Date: Date Created: 19930601 Date Completed: 19930805 Latest Revision: 20180109
- Publication Date: 20231215
- Accession Number: 10.1152/ajpheart.1993.264.6.H2141
- Accession Number: 8322945
- Source:
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