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9 a.m. - 6 p.m.
Phone: (843) 887-3699
Folly Beach Library
9 a.m. - 5:30 p.m.
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Miss Jane's Building (Edisto Library Temporary Location)
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Main Library
9 a.m. - 8 p.m.
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West Ashley Library
9 a.m. - 7 p.m.
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John L. Dart Library
9 a.m. - 7 p.m.
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St. Paul's/Hollywood Library
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Exhausted but Not Senescent T Lymphocytes Predominate in Lupus Nephritis Patients.
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- Author(s): Lioulios, Georgios; Mitsoglou, Zoi; Fylaktou, Asimina; Xochelli, Aliki; Christodoulou, Michalis; Stai, Stamatia; Moysidou, Eleni; Konstantouli, Afroditi; Nikolaidou, Vasiliki; Papagianni, Aikaterini; Stangou, Maria
- Source:
International Journal of Molecular Sciences; Nov2022, Vol. 23 Issue 22, p13928, 14p- Subject Terms:
- Source:
- Additional Information
- Abstract: Lupus nephritis (LN), a chronic inflammatory disease, is characterized by the substantial disruption of immune homeostasis. This study examines its effects on the T lymphocyte phenotype and, particularly, its senescence- and exhaustion-related immune alterations. T cell subpopulations were determined with flow cytometry in 30 LN patients and 20 healthy controls (HCs), according to the expression of senescence- (CD45RA, CCR7, CD31, CD28, CD57), and exhaustion- (PD1) related markers. The immune phenotype was associated with disease activity and renal histology. LN patients were characterized by pronounced lymphopenia, mainly affecting the CD4 compartment, with a concurrent reduction in the naïve, central and effector memory subsets compared to the HCs. In the CD8 compartment, the naïve subsets were significantly lower than that of the HCs, but a shift in the T cells occurred towards the central memory population. CD4+PD1+ and CD8+PD1+ cells were increased in the LN patients compared to the HCs. However, in CD4 T cells, the increase was limited to CD45RA+, whereas in CD8 T cells, both CD45RA+ and CD45RA− subsets were affected. Disease activity was correlated with CD4+PD1+ and highly differentiated CD4+CD28-CD57+ cells. Histology was only associated with CD4 T cell disturbances, with stage IV presenting reduced naïve and increased senescent subsets. Exhausted T lymphocyte subpopulations predominate within LN patients, while the T cell phenotype varies depending on disease activity. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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