Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA.

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    • Subject Terms:
      GENETIC regulation; RNA; GENES; DEVELOPMENTAL genetics
    • Abstract:
      Presents findings related to the role of the lin-4 and let-7 RNA genes. Detection of let-7 RNA of ~21 nucleotides in samples from a wide variety of animal species, but not in RNA from several cnidarian and poriferan species; Lack of lin-4 RNA in the species that contained let-7; Expression of let-7 RNA in Caenorhabditis elegans and Drosophila; Conclusion that the let-7 regulatory RNA may control late temporal transitions during development across animal phylogeny.