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Academic Journal

A novel co-culture model for investigation of the effects of LPS-induced macrophage-derived cytokines on brain endothelial cells.

Subjects: *ENDOTHELIAL cells; *INFLAMMATORY mediators; *CELL culture

  • Source: PLoS ONE. 7/13/2023, Vol. 18 Issue 7, p1-22. 22p.

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Development of novel salicylic acid–donepezil–rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.

Subjects: *ALZHEIMER'S disease; *BRAIN degeneration; *SCOPOLAMINE

  • Source: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2023, Vol. 38 Issue 1, p1-10. 10p.

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Evaluating the effect of rapamycin treatment in Alzheimer's disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol.

Subjects: *ALZHEIMER'S disease; *CEREBRAL amyloid angiopathy; *AGE factors in disease

  • Source: BMC Neurology. 4/4/2024, Vol. 24 Issue 1, p1-10. 10p.

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A privileged dual action Alzheimer's disease therapeutic platform targeting immunopathic and proteopathic mechanisms: (E)-3-styrylindoles as inhibitors of indoleamine 2,3-dioxygenase-mediated tryptophan metabolism and β-amyloid aggregation.

Subjects: *DIOXYGENASES; *ALZHEIMER'S disease; *MOLECULAR dynamics

  • Source: Canadian Journal of Chemistry. 2022, Vol. 100 Issue 9, p660-675. 16p.

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Academic Journal

Conserved age‐related increases in hippocampal PDE11A4 cause unexpected proteinopathies and cognitive decline of social associative memories.

Subjects: *COLLECTIVE memory; *RECOGNITION (Psychology); *COGNITION disorders

  • Source: Aging Cell. Oct2022, Vol. 21 Issue 10, p1-21. 21p.

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Explainability of three-dimensional convolutional neural networks for functional magnetic resonance imaging of Alzheimer's disease classification based on gradient-weighted class activation mapping.

Subjects: *FUNCTIONAL magnetic resonance imaging; *CONVOLUTIONAL neural networks; *ALZHEIMER'S disease

  • Source: PLoS ONE. 5/21/2024, Vol. 19 Issue 5, p1-22. 22p.

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Unraveling the genetic architecture of blood unfolded p-53 among non-demented elderlies: novel candidate genes for early Alzheimer's disease.

Subjects: *ALZHEIMER'S disease; *OLDER people; *GENOME-wide association studies

  • Source: BMC Genomics. 5/3/2024, Vol. 25 Issue 1, p1-15. 15p.

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Academic Journal

Acupuncture Effect Assessment in APP/PS1 Transgenic Mice: On Regulating Learning-Memory Abilities, Gut Microbiota, and Microbial Metabolites.

Subjects: *MICROBIAL metabolites; *TRANSGENIC mice; *GUT microbiome

  • Source: Computational & Mathematical Methods in Medicine. 4/8/2022, p1-20. 20p.

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Characterization in nonhuman primates of (R)-[18F]OF-Me-NB1 and (S)-[18F]OF-Me-NB1 for imaging the GluN2B subunits of the NMDA receptor.

Subjects: *METHYL aspartate receptors; *NEURAL transmission; *NEURODEGENERATION

  • Source: European Journal of Nuclear Medicine & Molecular Imaging. Jun2022, Vol. 49 Issue 7, p2153-2162. 10p. 1 Diagram, 1 Chart, 5 Graphs.

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Academic Journal

Blueberry extracts antagonize Aβ25–35 neurotoxicity and exert a neuroprotective effect through MEK-ERK-BDNF/UCH-L1 signaling pathway in rat and mouse hippocampus.

Subjects: *BLUEBERRIES; *CELLULAR signal transduction; *ALZHEIMER'S disease

  • Source: Nutritional Neuroscience. Jul2024, Vol. 27 Issue 7, p745-760. 16p.

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  • 1-10 of  403 results for "Yang%2C%20Kelly"