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Academic Journal

Kinetics of tienilic acid bioactivation and functional generation of drug-protein adducts in intact rat hepatocytes.

  • Authors : López-García MP; Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Valencia, Valencia, Spain. ; Dansette PM

Subjects: Hepatocytes/Hepatocytes/Hepatocytes/*metabolism ; Ticrynafen/Ticrynafen/Ticrynafen/*pharmacokinetics; Animals

  • Source: Biochemical pharmacology [Biochem Pharmacol] 2005 Dec 05; Vol. 70 (12), pp. 1870-82. Date of Electronic Publication: 2005 Oct 28.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Print ISSN:

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Academic Journal

Substrate selectivity of human cytochrome P450 2C9: importance of residues 476, 365, and 114 in recognition of diclofenac and sulfaphenazole and in mechanism-based inactivation by tienilic acid.

  • Authors : Melet A; Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Université Paris V, 45 Rue des Saints-Pères, 75270 06 Paris Cedex, France.; Assrir N

Subjects: Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/*chemistry ; Diclofenac/Diclofenac/Diclofenac/*pharmacology ; Sulfaphenazole/Sulfaphenazole/Sulfaphenazole/*pharmacology

  • Source: Archives of biochemistry and biophysics [Arch Biochem Biophys] 2003 Jan 01; Vol. 409 (1), pp. 80-91.Publisher: Elsevier Country of Publication: United States NLM ID: 0372430 Publication Model: Print Cited Medium: Print ISSN: 0003-9861 (Print)

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Academic Journal

Use of isotopes and LC-MS-ESI-TOF for mechanistic studies of tienilic acid metabolic activation.

  • Authors : Belghazi M; Université René Descartes, CNRS UMR 8601 Paris, France.; Jean P

Subjects: Aryl Hydrocarbon Hydroxylases* ; Steroid 16-alpha-Hydroxylase*; Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/*metabolism

  • Source: Advances in experimental medicine and biology [Adv Exp Med Biol] 2001; Vol. 500, pp. 139-44.Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 0121103 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

Comparison of the substrate specificities of human liver cytochrome P450s 2C9 and 2C18: application to the design of a specific substrate of CYP 2C18.

  • Authors : Minoletti C; Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, URA400 CNRS, Université Paris V, Paris, France.; Dijols S

Subjects: Aryl Hydrocarbon Hydroxylases* ; Steroid 16-alpha-Hydroxylase*; Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/*chemistry

  • Source: Biochemistry [Biochemistry] 1999 Jun 15; Vol. 38 (24), pp. 7828-36.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

Opposite behaviors of reactive metabolites of tienilic acid and its isomer toward liver proteins: use of specific anti-tienilic acid-protein adduct antibodies and the possible relationship with different hepatotoxic effects of the two compounds.

  • Authors : Bonierbale E; Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, URA 400 CNRS, Université Paris V, 45 rue des Saints-Pères, 75270 Paris Cedex 06, France.; Valadon P

Subjects: Antibodies* ; Aryl Hydrocarbon Hydroxylases* ; Steroid 16-alpha-Hydroxylase*

  • Source: Chemical research in toxicology [Chem Res Toxicol] 1999 Mar; Vol. 12 (3), pp. 286-96.Publisher: American Chemical Society Country of Publication: United States NLM ID: 8807448 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

The substrate binding site of human liver cytochrome P450 2C9: an approach using designed tienilic acid derivatives and molecular modeling.

  • Authors : Mancy A; Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, URA 400 CNRS, Université Paris V, France.; Broto P

Subjects: Aryl Hydrocarbon Hydroxylases* ; Models, Molecular* ; Steroid 16-alpha-Hydroxylase*

  • Source: Biochemistry [Biochemistry] 1995 Aug 22; Vol. 34 (33), pp. 10365-75.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

Specificity of in vitro covalent binding of tienilic acid metabolites to human liver microsomes in relationship to the type of hepatotoxicity: comparison with two directly hepatotoxic drugs.

  • Authors : Lecoeur S; Institut National de la Santé et de la Recherche Médicale U75, CHU Necker-Enfants-Malades, Université René Descartes, Paris, France.; Bonierbale E

Subjects: Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/*metabolism ; Microsomes, Liver/Microsomes, Liver/Microsomes, Liver/*metabolism ; Ticrynafen/Ticrynafen/Ticrynafen/*metabolism

  • Source: Chemical research in toxicology [Chem Res Toxicol] 1994 May-Jun; Vol. 7 (3), pp. 434-42.Publisher: American Chemical Society Country of Publication: United States NLM ID: 8807448 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid.

  • Authors : López-Garcia MP; Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, URA 400 CNRS, Université René Descartes, Paris, France.; Dansette PM

Subjects: Aryl Hydrocarbon Hydroxylases* ; Cytochrome P-450 Enzyme Inhibitors* ; Steroid 16-alpha-Hydroxylase*

  • Source: Biochemistry [Biochemistry] 1994 Jan 11; Vol. 33 (1), pp. 166-75.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

Human-liver cytochromes P-450 expressed in yeast as tools for reactive-metabolite formation studies. Oxidative activation of tienilic acid by cytochromes P-450 2C9 and 2C10.

  • Authors : Lopez Garcia MP; Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Centre National de la Recherche Scientifique, Université René Descartes, Paris, France.; Dansette PM

Subjects: Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/*genetics ; Isoenzymes/Isoenzymes/Isoenzymes/*metabolism ; Microsomes, Liver/Microsomes, Liver/Microsomes, Liver/*enzymology

  • Source: European journal of biochemistry [Eur J Biochem] 1993 Apr 01; Vol. 213 (1), pp. 223-32.Publisher: Blackwell Science Ltd. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 0107600 Publication Model:

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Academic Journal

Hydroxylation and formation of electrophilic metabolites of tienilic acid and its isomer by human liver microsomes. Catalysis by a cytochrome P450 IIC different from that responsible for mephenytoin hydroxylation.

  • Authors : Dansette PM; Unité de Recherche Associée au CNRS (URA 400), Université René Descartes, Paris, France.; Amar C

Subjects: Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/Cytochrome P-450 Enzyme System/*physiology ; Isoenzymes/Isoenzymes/Isoenzymes/*physiology ; Mephenytoin/Mephenytoin/Mephenytoin/*metabolism

  • Source: Biochemical pharmacology [Biochem Pharmacol] 1991 Feb 15; Vol. 41 (4), pp. 553-60.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print Cited Medium: Print ISSN: 0006-2952 (Print)

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  • 1-10 of  13 results for ""Dansette PM""