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Academic Journal

Oxidative activation of the thiophene ring by hepatic enzymes. Hydroxylation and formation of electrophilic metabolites during metabolism of tienilic acid and its isomer by rat liver microsomes.

  • Authors : Dansette PM; Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université René Descartes, Paris, France.; Amar C

Subjects: Glycolates/Glycolates/Glycolates/*metabolism ; Microsomes, Liver/Microsomes, Liver/Microsomes, Liver/*enzymology ; NADP/NADP/NADP/*metabolism

  • Source: Biochemical pharmacology [Biochem Pharmacol] 1990 Mar 01; Vol. 39 (5), pp. 911-8.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print Cited Medium: Print ISSN: 0006-2952 (Print)

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Academic Journal

A dissolution anomaly involving ticrynafen in simulated intestinal fluid without enzyme.

Subjects: Glycolates* ; Potassium* ; Ticrynafen*

  • Source: Journal of pharmaceutical sciences [J Pharm Sci] 1982 Apr; Vol. 71 (4), pp. 406-9.Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print Cited Medium: Print ISSN: 0022-3549 (Print)

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Academic Journal

Metabolic hydroxylation of the thiophene ring: isolation of 5-hydroxy-tienilic acid as the major urinary metabolite of tienilic acid in man and rat.

Subjects: Glycolates/Glycolates/Glycolates/*metabolism ; Glycolates/Glycolates/Glycolates/*urine ; Ticrynafen/Ticrynafen/Ticrynafen/*metabolism

  • Source: Biochemical pharmacology [Biochem Pharmacol] 1984 May 01; Vol. 33 (9), pp. 1429-35.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print Cited Medium: Print ISSN: 0006-2952 (Print)

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Academic Journal

[Acute renal failure after administration of tienilic acid (author's transl)].

Subjects: Acute Kidney Injury/Acute Kidney Injury/Acute Kidney Injury/*chemically induced ; Glycolates/Glycolates/Glycolates/*adverse effects ; Ticrynafen/Ticrynafen/Ticrynafen/*adverse effects

  • Source: Therapie [Therapie] 1981 Jan-Feb; Vol. 36 (1), pp. 47-53.Publisher: Elsevier Masson Country of Publication: France NLM ID: 0420544 Publication Model: Print Cited Medium: Print ISSN: 0040-5957 (Print)

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Academic Journal

Effect of the glutathione S-transferase inhibitor, tienilic acid, on biliary excretion of sulphobromophthalein.

  • Authors : Fehring SI; Department of Applied Biology, Royal Melbourne Institute of Technology, Victoria, Australia.; Ahokas JT

Subjects: Glutathione Transferase/Glutathione Transferase/Glutathione Transferase/*antagonists & inhibitors ; Glycolates/Glycolates/Glycolates/*pharmacology ; Sulfobromophthalein/Sulfobromophthalein/Sulfobromophthalein/*metabolism

  • Source: Chemico-biological interactions [Chem Biol Interact] 1989; Vol. 69 (1), pp. 23-32.Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print Cited Medium: Print ISSN: 0009-2797 (Print)

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Academic Journal

[Diuretics and vascular risk factors. Comparison between tienilic acid and chlorothiazide (author's transl)].

Subjects: Lipid Metabolism*; Blood Glucose/Blood Glucose/Blood Glucose/*metabolism ; Blood Pressure/Blood Pressure/Blood Pressure/*drug effects

  • Source: Nephrologie [Nephrologie] 1981; Vol. 2 (3), pp. 96-101.Publisher: Médecine et Hygiène Country of Publication: Switzerland NLM ID: 8011169 Publication Model: Print Cited Medium: Print ISSN:

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Editorial & Opinion

Relative costs of ticrynafen and thiazides.

Subjects: Costs and Cost Analysis*; Glycolates/Glycolates/Glycolates/*therapeutic use ; Hydrochlorothiazide/Hydrochlorothiazide/Hydrochlorothiazide/*therapeutic use

  • Source: The New England journal of medicine [N Engl J Med] 1979 Dec 13; Vol. 301 (24), pp. 1346.Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

[Tienilic acid as a likely cause of "auto immune" active hepatitis (author's transl)].

Subjects: Autoimmune Diseases/Autoimmune Diseases/Autoimmune Diseases/*chemically induced ; Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/Chemical and Drug Induced Liver Injury/*etiology ; Glycolates/Glycolates/Glycolates/*adverse effects

  • Source: La Nouvelle presse medicale [Nouv Presse Med] 1980 Jun 21; Vol. 9 (27), pp. 1885-7.Publisher: Masson Country of Publication: France NLM ID: 0312552 Publication Model: Print Cited Medium: Print ISSN: 0301-1518 (Print) Linking

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Academic Journal

[Diuretic treatment and serum lipoproteins: effects of tienilic acid and indapamide (author's transl)].

Subjects: Diuretics/Diuretics/Diuretics/*therapeutic use ; Glycolates/Glycolates/Glycolates/*therapeutic use ; Hypertension/Hypertension/Hypertension/*drug therapy

  • Source: Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis [Schweiz Rundsch Med Prax] 1982 Feb 16; Vol. 71 (7), pp. 289-92.Publisher: Verlag Hans Huber Country of Publication: Switzerland NLM ID: 8403202 Publication Model: Print Cited Medium: Print ISSN: 1013-2058

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Academic Journal

Ticrynafen-induced acute renal failure.

Subjects: Acute Kidney Injury/Acute Kidney Injury/Acute Kidney Injury/*chemically induced ; Glycolates/Glycolates/Glycolates/*adverse effects ; Ticrynafen/Ticrynafen/Ticrynafen/*adverse effects

  • Source: Clinical toxicology [Clin Toxicol] 1981 Apr; Vol. 18 (4), pp. 425-30.Publisher: Dekker Country of Publication: United States NLM ID: 0205535 Publication Model: Print Cited Medium: Print ISSN: 0009-9309 (Print)

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