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Publication : journal of clinical investigation Subject : apoptosis Subject : interleukins Filter by : Subject

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Academic Journal

Cyclin G1 induces maladaptive proximal tubule cell dedifferentiation and renal fibrosis through CDK5 activation.

Authors : Kensei Taguchi; Elias, Bertha C.; Sho Sugahara

Subjects: RENAL fibrosis; KIDNEY tubules; CYCLINS

Source: Journal of Clinical Investigation. 12/1/2022, Vol. 132 Issue 23, p1-16. 16p.

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Academic Journal

Bone marrow-confined IL-6 signaling mediates the progression of myelodysplastic syndromes to acute myeloid leukemia.

Authors : Yang Mei; Ren, Kehan; Yijie Liu

Subjects: MYELODYSPLASTIC syndromes; INTERLEUKINS; ANIMAL experimentation

Source: Journal of Clinical Investigation. 9/1/2022, Vol. 132 Issue 17, p1-16. 16p.

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Academic Journal

Kidney VISTA prevents IFN-γ/IL-9 axis-mediated tubulointerstitial fibrosis after acute glomerular injury.

Authors : Min-Gang Kim; Donghwan Yun; Chae Lin Kang

Subjects: REGULATORY T cells; FIBROSIS; INTERSTITIAL cells

Source: Journal of Clinical Investigation. Jan2022, Vol. 132 Issue 1, p1-15. 16p.

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Academic Journal

MicroRNA-26a-3p rescues depression-like behaviors in male rats via preventing hippocampal neuronal anomalies.

Authors : Ye Li; Cuiqin Fan; Liyan Wang

Subjects: RATS; DENTATE gyrus; HIPPOCAMPUS (Brain)

Source: Journal of Clinical Investigation. 8/16/2021, Vol. 131 Issue 16, p1-18. 19p.

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Academic Journal

A therapeutic cancer vaccine delivers antigens and adjuvants to lymphoid tissues using genetically modified T cells.

Authors : Veatch, Joshua R.; Singhi, Naina; Srivastava, Shivani

Subjects: T cells; LYMPHOID tissue; CANCER vaccines

Source: Journal of Clinical Investigation. 8/16/2021, Vol. 131 Issue 16, p1-15. 16p. 1 Illustration.

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Academic Journal

Cytomegalovirus mediates expansion of IL-15-responsive innate-memory cells with SIV killing function.

Authors : Méndez-Lagares, Gema; Ning Chin; Chang, W. L. William

Subjects: ANTIGEN presenting cells; T cells; CYTOMEGALOVIRUSES

Source: Journal of Clinical Investigation. 8/2/2021, Vol. 131 Issue 15, p1-15. 15p.

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Academic Journal

Basophils balance healing after myocardial infarction via IL-4/IL-13.

Authors : Sicklinger, Florian; Sören Meyer, Ingmar; Xue Li

Subjects: BASOPHILS; MYOCARDIAL infarction; HEALING

Source: Journal of Clinical Investigation. 7/1/2021, Vol. 131 Issue 13, p1-12. 12p.

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Academic Journal

IL-23 reshapes kidney resident cell metabolism and promotes local kidney inflammation.

Authors : Hao Li; Tsokos, Maria G.; Bhargava, Rhea

Subjects: CELL metabolism; INTERLEUKIN-23; INTRACELLULAR calcium

Source: Journal of Clinical Investigation. 6/15/2021, Vol. 131 Issue 12, p1-15. 15p.

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Academic Journal

The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics.

Authors : Giblin, William; Bringman-Rodenbarger, Lauren; Guo, Angela H.

Subjects: MELANOMA; IMMUNE checkpoint proteins; CHROMATIN

Source: Journal of Clinical Investigation. 6/15/2021, Vol. 131 Issue 12, p1-18. 18p.

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Academic Journal

FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition.

Authors : Reilly, Shannon M.; Abu-Odeh, Mohammad; Ameka, Magdalene

Subjects: FIBROBLAST growth factors; WHITE adipose tissue; WEIGHT loss

Source: Journal of Clinical Investigation. 5/17/2021, Vol. 131 Issue 10, p1-15. 15p. 1 Color Photograph, 7 Graphs.

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