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Academic Journal

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.

  • Authors : Wyllie S; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK.; Thomas M

Subjects: Molecular Targeted Therapy*; Cyclin-Dependent Kinases/Cyclin-Dependent Kinases/Cyclin-Dependent Kinases/*antagonists & inhibitors ; Leishmania donovani/Leishmania donovani/Leishmania donovani/*drug effects

  • Source: Nature [Nature] 2018 Aug; Vol. 560 (7717), pp. 192-197. Date of Electronic Publication: 2018 Jul 25.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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Academic Journal

Molecular basis of USP7 inhibition by selective small-molecule inhibitors.

  • Authors : Turnbull AP; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London NW1 0NH, UK.; Ioannidis S

Subjects: Piperidines/Piperidines/Piperidines/*pharmacology ; Pyrazoles/Pyrazoles/Pyrazoles/*pharmacology ; Pyrimidines/Pyrimidines/Pyrimidines/*pharmacology

  • Source: Nature [Nature] 2017 Oct 26; Vol. 550 (7677), pp. 481-486. Date of Electronic Publication: 2017 Oct 18.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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Academic Journal

A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis.

Subjects: 1-Phosphatidylinositol 4-Kinase/1-Phosphatidylinositol 4-Kinase/1-Phosphatidylinositol 4-Kinase/*antagonists & inhibitors ; Cryptosporidiosis/Cryptosporidiosis/Cryptosporidiosis/*drug therapy ; Cryptosporidiosis/Cryptosporidiosis/Cryptosporidiosis/*parasitology

  • Source: Nature [Nature] 2017 Jun 15; Vol. 546 (7658), pp. 376-380. Date of Electronic Publication: 2017 May 31.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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Academic Journal

The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.

  • Authors : Wylie AA; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA.; Schoepfer J

Subjects: Allosteric Site/Allosteric Site/Allosteric Site/*drug effects ; Fusion Proteins, bcr-abl/Fusion Proteins, bcr-abl/Fusion Proteins, bcr-abl/*antagonists & inhibitors ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/Leukemia, Myelogenous, Chronic, BCR-ABL Positive/Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*drug therapy

  • Source: Nature [Nature] 2017 Mar 30; Vol. 543 (7647), pp. 733-737. Date of Electronic Publication: 2017 Mar 22.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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Academic Journal

Extra-helical binding site of a glucagon receptor antagonist.

  • Authors : Jazayeri A; Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.; Doré AS

Subjects: Pyrazoles/Pyrazoles/Pyrazoles/*metabolism ; Receptors, Glucagon/Receptors, Glucagon/Receptors, Glucagon/*antagonists & inhibitors ; Receptors, Glucagon/Receptors, Glucagon/Receptors, Glucagon/*chemistry

  • Source: Nature [Nature] 2016 May 12; Vol. 533 (7602), pp. 274-7. Date of Electronic Publication: 2016 Apr 25.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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Academic Journal

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.

  • Authors : Huber KV; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.; Salah E

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; DNA Repair Enzymes/DNA Repair Enzymes/DNA Repair Enzymes/*antagonists & inhibitors ; DNA Repair Enzymes/DNA Repair Enzymes/DNA Repair Enzymes/*metabolism

  • Source: Nature [Nature] 2014 Apr 10; Vol. 508 (7495), pp. 222-7. Date of Electronic Publication: 2014 Apr 02.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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Academic Journal

Precision therapies take aim at non-Hodgkin's lymphoma.

Subjects: Molecular Targeted Therapy*; Agammaglobulinaemia Tyrosine Kinase/Agammaglobulinaemia Tyrosine Kinase/Agammaglobulinaemia Tyrosine Kinase/*antagonists & inhibitors ; Lymphoma, Non-Hodgkin/Lymphoma, Non-Hodgkin/Lymphoma, Non-Hodgkin/*immunology

  • Source: Nature [Nature] 2018 Nov; Vol. 563 (7731), pp. S46-S47.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium:

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Periodical

Crunch time for peer review in lawsuit.

Subjects: Drug Industry* ; Isoxazoles*/Isoxazoles*/Isoxazoles*/adverse effects ; Isoxazoles*/Isoxazoles*/Isoxazoles*/pharmacology

  • Source: Nature [Nature] 2008 Mar 06; Vol. 452 (7183), pp. 6-7.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium:

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Periodical

Targeted treatment tested as potential cancer cure.

Subjects: Molecular Targeted Therapy*/Molecular Targeted Therapy*/Molecular Targeted Therapy*/trends; Lung Neoplasms/Lung Neoplasms/Lung Neoplasms/*drug therapy ; Pyrazoles/Pyrazoles/Pyrazoles/*therapeutic use

  • Source: Nature [Nature] 2011 Nov 16; Vol. 479 (7373), pp. 281. Date of Electronic Publication: 2011 Nov 16.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Electronic Cited

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Periodical

Appetite downer awaits approval.

Subjects: Appetite Depressants*/Appetite Depressants*/Appetite Depressants*/adverse effects ; Appetite Depressants*/Appetite Depressants*/Appetite Depressants*/economics ; Appetite Depressants*/Appetite Depressants*/Appetite Depressants*/supply & distribution

  • Source: Nature [Nature] 2005 Sep 29; Vol. 437 (7059), pp. 618-9.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium:

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  • 1-10 of  98 results for ""Pyrazoles""