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Publication : proceedings of the national academy of sciences of the united states of america Filter by : Subject

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Academic Journal

Mechanism and site of action of big dynorphin on ASIC1a.

Authors : Borg, Christian B.; Braun, Nina; Heusser, Stephanie A.

Subjects: ACID-sensing ion channels; DYNORPHINS; BIOCHEMICAL mechanism of action

Source: Proceedings of the National Academy of Sciences of the United States of America; 3/31/2020, Vol. 117 Issue 13, p7447-7454, 8p

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Academic Journal

Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome.

Authors : Hong Lin; Xiaozhe Zhang; Li Liu

Subjects: SMALL molecules; SCHIZOSACCHAROMYCES pombe; ELECTRON density

Source: Proceedings of the National Academy of Sciences of the United States of America; 2/25/2020, Vol. 117 Issue 8, p4117-4124, 8p

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Academic Journal

An inhibitor of complement C5 provides structural insights into activation.

Authors : Reichhardt, Martin P.; Johnson, Steven; Tang, Terence

Subjects: COMPLEMENT inhibition; X-ray crystallography; COMPLEMENT activation

Source: Proceedings of the National Academy of Sciences of the United States of America; 1/7/2020, Vol. 117 Issue 1, p362-370, 9p

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Academic Journal

Structure of a Tc holotoxin pore provides insights into the translocation mechanism.

Authors : Roderer, Daniel; Hofnagel, Oliver; Benz, Roland

Subjects: PHOTORHABDUS luminescens; PATHOGENIC bacteria; TOXINS

Source: Proceedings of the National Academy of Sciences of the United States of America; 11/12/2019, Vol. 116 Issue 46, p23083-23090, 8p

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Academic Journal

Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma.

Authors : AbuHammad, Shatha; Cullinane, Carleen; Martin, Claire

Subjects: PROTEIN arginine methyltransferases; MELANOMA; PROTEIN expression

Source: Proceedings of the National Academy of Sciences of the United States of America; 9/3/2019, Vol. 116 Issue 36, p17990-18000, 11p

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Academic Journal

Prion protein quantification in human cerebrospinal fluid as a tool for prion disease drug development.

Authors : Vallabh, Sonia M.; Nobuhara, Chloe K.; Llorens, Franc

Subjects: PRIONS; DRUG development; PRION disease treatment

Source: Proceedings of the National Academy of Sciences of the United States of America; 4/16/2019, Vol. 116 Issue 16, p7793-7798, 6p

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Academic Journal

Clues to mechanisms of herpesviral latent infection and potential cures.

Authors : Knipe, David M.¹ ; Raja, Priya¹; Lee, Jennifer S.¹

Subjects: *HERPES simplex treatment; *BIOCHEMICAL mechanism of action; *LATENT infection

Source: Proceedings of the National Academy of Sciences of the United States of America. 9/29/2015, Vol. 112 Issue 39, p11993-11994. 2p.

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Academic Journal

Intrinsic excitability measures track antiepileptic drug action and uncover increasing/decreasing excitability over the wake/sleep cycle.

Authors : Meisel, Christian; Schulze-Bonhage, Andreas; Freestone, Dean

Subjects: ANTICONVULSANTS; SLEEP-wake cycle; BIOCHEMICAL mechanism of action

Source: Proceedings of the National Academy of Sciences of the United States of America; 11/24/2015, Vol. 112 Issue 47, p14694-14699, 6p

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Academic Journal

Defining principles of combination drug mechanisms of action.

Authors : Pritchard, Justin R.¹; Bruno, Peter M.¹; Gilbert, Luke A.¹

Subjects: *DRUG development; *BIOCHEMICAL mechanism of action

Source: Proceedings of the National Academy of Sciences of the United States of America. 1/8/2013, Vol. 110 Issue 2, p403-404. 2p.

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Academic Journal

Mechanisms of damage to corals exposed to sedimentation.

Authors : Weber, Miriam¹ ; de Beer, Dirk²; Lott, Christian³

Subjects: *BIOCHEMICAL mechanism of action; *CORALS; *SEDIMENTATION & deposition

Source: Proceedings of the National Academy of Sciences of the United States of America. 06122012, Vol. 109 Issue 24, p9242-9243. 2p.

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