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Academic Journal

Structural basis of insulin fibrillation.

  • Authors : Wang L; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Hall CE

Subjects: Diabetes Mellitus, Type 1*/Diabetes Mellitus, Type 1*/Diabetes Mellitus, Type 1*/drug therapy ; Insulin*/Insulin*/Insulin*/chemistry ; Insulin*/Insulin*/Insulin*/physiology

  • Source: Science advances [Sci Adv] 2023 Sep 15; Vol. 9 (37), pp. eadi1057. Date of Electronic Publication: 2023 Sep 15.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication

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Academic Journal

An ultrafast insulin formulation enabled by high-throughput screening of engineered polymeric excipients.

  • Authors : Mann JL; Department of Materials Science and Engineering, Stanford University, Stanford, CA 94025, USA.; Maikawa CL

Subjects: Diabetes Mellitus, Type 2* ; Insulin*; Animals

  • Source: Science translational medicine [Sci Transl Med] 2020 Jul 01; Vol. 12 (550).Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication

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Academic Journal

Remote activation of cellular signaling.

  • Authors : Brier MI; Department of Chemical and Biological Engineering and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.; Dordick JS

Subjects: Diabetes Mellitus, Experimental* ; Insulin*; Animals

  • Source: Science (New York, N.Y.) [Science] 2020 May 29; Vol. 368 (6494), pp. 936-937.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Academic Journal

Position β57 of I-A g7 controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset.

  • Authors : Gioia L; Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.; Holt M

Subjects: Alleles*; Diabetes Mellitus, Type 1/Diabetes Mellitus, Type 1/Diabetes Mellitus, Type 1/*immunology ; Insulin/Insulin/Insulin/*immunology

  • Source: Science immunology [Sci Immunol] 2019 Aug 30; Vol. 4 (38).Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication

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Academic Journal

How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.

  • Authors : Wang Y; Department of Biomedical Research, National Jewish Health, Denver, CO 80206, USA.; Department of Immunology and Microbiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Subjects: Autoantigens/Autoantigens/Autoantigens/*immunology ; CD4-Positive T-Lymphocytes/CD4-Positive T-Lymphocytes/CD4-Positive T-Lymphocytes/*immunology ; Diabetes Mellitus, Type 1/Diabetes Mellitus, Type 1/Diabetes Mellitus, Type 1/*immunology

  • Source: Science immunology [Sci Immunol] 2019 Apr 05; Vol. 4 (34).Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication

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Academic Journal

β-cell-mimetic designer cells provide closed-loop glycemic control.

  • Authors : Xie M; Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland.; Ye H

Subjects: Blood Glucose/Blood Glucose/Blood Glucose/*metabolism ; Diabetes Mellitus, Type 1/Diabetes Mellitus, Type 1/Diabetes Mellitus, Type 1/*therapy ; Diabetes Mellitus, Type 2/Diabetes Mellitus, Type 2/Diabetes Mellitus, Type 2/*therapy

  • Source: Science (New York, N.Y.) [Science] 2016 Dec 09; Vol. 354 (6317), pp. 1296-1301.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Academic Journal

Synthetic "smart gel" provides glucose-responsive insulin delivery in diabetic mice.

  • Authors : Matsumoto A; Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.; Tanaka M

Subjects: Diabetes Mellitus, Experimental/Diabetes Mellitus, Experimental/Diabetes Mellitus, Experimental/*drug therapy ; Drug Carriers/Drug Carriers/Drug Carriers/*chemistry ; Gels/Gels/Gels/*chemistry

  • Source: Science advances [Sci Adv] 2017 Nov 22; Vol. 3 (11), pp. eaaq0723. Date of Electronic Publication: 2017 Nov 22 (Print Publication: 2017).Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication

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Academic Journal

Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs.

  • Authors : Wang J; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, USA.

Subjects: Drug Delivery Systems*; Drug Carriers/Drug Carriers/Drug Carriers/*chemistry ; Insulin/Insulin/Insulin/*administration & dosage

  • Source: Science advances [Sci Adv] 2019 Jul 10; Vol. 5 (7), pp. eaaw4357. Date of Electronic Publication: 2019 Jul 10 (Print Publication: 2019).Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication

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Academic Journal

Insulin B chain 9-23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3+ Tregs.

  • Authors : Akbarpour M; San Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cells and Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy. Vita-Salute San Raffaele University, Milan 20132, Italy.; Goudy KS

Subjects: Gene Transfer Techniques*; Antigens/Antigens/Antigens/*immunology ; Diabetes Mellitus, Type 1/Diabetes Mellitus, Type 1/Diabetes Mellitus, Type 1/*immunology

  • Source: Science translational medicine [Sci Transl Med] 2015 May 27; Vol. 7 (289), pp. 289ra81.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication

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Academic Journal

Insulin signaling in health and disease.

  • Authors : White MF; Howard Hughes Medical Institute, Joslin Diabetes Center, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA.

Subjects: Insulin Resistance* ; Signal Transduction*; Diabetes Mellitus/Diabetes Mellitus/Diabetes Mellitus/*metabolism

  • Source: Science (New York, N.Y.) [Science] 2003 Dec 05; Vol. 302 (5651), pp. 1710-1.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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