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Publisher : american society for clinical investigation Subject : apoptosis Subject : research methodology Filter by : Subject

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Academic Journal

Cyclin G1 induces maladaptive proximal tubule cell dedifferentiation and renal fibrosis through CDK5 activation.

Authors : Kensei Taguchi; Elias, Bertha C.; Sho Sugahara

Subjects: RENAL fibrosis; KIDNEY tubules; CYCLINS

Source: Journal of Clinical Investigation. 12/1/2022, Vol. 132 Issue 23, p1-16. 16p.

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Academic Journal

p38 MAPK reins in right ventricular growth.

Authors : Wu, Tongbin (AUTHOR); Chen, Ju (AUTHOR)

Subjects: *ANIMAL experimentation; *COMPARATIVE studies; *ESTERASES

Source: Journal of Clinical Investigation. Oct2020, Vol. 130 Issue 10, p5109-5111. 3p.

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Academic Journal

Tumor-specific interendothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness.

Authors : Tomofumi Ando; Ikue Tai-Nagara; Yuki Sugiura

Subjects: MEMBRANE proteins; CANCER invasiveness; IMMUNE checkpoint proteins

Source: Journal of Clinical Investigation. 3/15/2022, Vol. 132 Issue 6, p1-16. 16p.

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Academic Journal

An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment.

Authors : Bing Yang; Zhen Zhang; Xiangjun Chen

Subjects: TUMOR microenvironment; IMMUNOLOGIC memory; B cell receptors

Source: Journal of Clinical Investigation. 3/15/2022, Vol. 132 Issue 6, p1-18. 18p.

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Academic Journal

Antiphospholipid autoantibodies in Lyme disease arise after scavenging of host phospholipids by Borrelia burgdorferi.

Authors : Gwynne, Peter J.; Clendenen, Luke H.; Siu-Ping Turk

Subjects: LYME disease; BORRELIA burgdorferi; PHOSPHOLIPIDS

Source: Journal of Clinical Investigation. 3/15/2022, Vol. 132 Issue 6, p1-14. 14p.

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Academic Journal

YAP mediates compensatory cardiac hypertrophy through aerobic glycolysis in response to pressure overload.

Authors : Toshihide Kashihara; Mukai, Risa; Shin-ichi Oka

Subjects: CARDIAC hypertrophy; YAP signaling proteins; HIPPO signaling pathway

Source: Journal of Clinical Investigation. 3/15/2022, Vol. 132 Issue 6, p1-21. 21p.

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Academic Journal

Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms.

Authors : Salamone, Isabella M.; Quattrocelli, Mattia; Barefield, David Y.

Subjects: SKELETAL muscle; GLUCOCORTICOIDS; MUSCLE weakness

Source: Journal of Clinical Investigation. 3/15/2022, Vol. 132 Issue 6, p1-17. 17p.

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Academic Journal

Lysosomal exocytosis of HSP70 stimulates monocytic BMP6 expression in Sjögren's syndrome.

Authors : Ying-Qian Mo; Hiroyuki Nakamura; Tsutomu Tanaka

Subjects: SJOGREN'S syndrome; EXOCYTOSIS; SALIVARY glands

Source: Journal of Clinical Investigation. 3/15/2022, Vol. 132 Issue 6, p1-14. 14p.

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Academic Journal

USP25 inhibition ameliorates Alzheimer's pathology through the regulation of APP processing and Aβ generation.

Authors : Qiuyang Zheng; Beibei Song; Guilin Li

Subjects: ALZHEIMER'S disease; BRAIN diseases; BACTERIAL artificial chromosomes

Source: Journal of Clinical Investigation. Mar2022, Vol. 132 Issue 5, p1-12. 12p.

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Academic Journal

ATP11B inhibits breast cancer metastasis in a mouse model by suppressing externalization of nonapoptotic phosphatidylserine.

Authors : Jun Xu; Sek Man Su; Xin Zhang

Subjects: METASTATIC breast cancer; PHOSPHATIDYLSERINES; PACLITAXEL

Source: Journal of Clinical Investigation. Mar2022, Vol. 132 Issue 5, p1-19. 19p.

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