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Academic Journal

PKM2 induces mitophagy through the AMPK-mTOR pathway promoting CSFV proliferation.

  • Authors : Liu X; College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guang Dong, China.; Yan Q

Subjects: AMP-Activated Protein Kinases*/AMP-Activated Protein Kinases*/AMP-Activated Protein Kinases*/metabolism ; Classical Swine Fever Virus*/Classical Swine Fever Virus*/Classical Swine Fever Virus*/growth & development ; Classical Swine Fever Virus*/Classical Swine Fever Virus*/Classical Swine Fever Virus*/physiology

  • Source: Journal of virology [J Virol] 2024 Mar 19; Vol. 98 (3), pp. e0175123. Date of Electronic Publication: 2024 Feb 06.Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model:

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Academic Journal

Variability in the Responses of Hepatitis B Virus D-Subgenotypes to Antiviral Therapy: Designing Pan-D-Subgenotypic Reverse Transcriptase Inhibitors.

  • Authors : Khatun M; Centre for Liver Research, School of Digestive and Liver Diseases, Institute of Post Graduate Medical Education and Research, Kolkata, India.; Kumar K

Subjects: Drug Design*; Antiviral Agents/Antiviral Agents/Antiviral Agents/*pharmacology ; Hepatitis B virus/Hepatitis B virus/Hepatitis B virus/*drug effects

  • Source: Journal of virology [J Virol] 2022 Jan 26; Vol. 96 (2), pp. e0180021. Date of Electronic Publication: 2021 Nov 03.Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model:

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Academic Journal

Designing the Next Generation of Vaccines: Relevance for Future Pandemics.

  • Authors : Domínguez-Andrés J; Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands .; Radboud Center for Infectious diseases (RCI), Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

Subjects: Drug Design* ; Immunomodulation*; Adjuvants, Immunologic/Adjuvants, Immunologic/Adjuvants, Immunologic/*administration & dosage

  • Source: MBio [mBio] 2020 Dec 22; Vol. 11 (6). Date of Electronic Publication: 2020 Dec 22.Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model:

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Academic Journal

Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors.

  • Authors : Matthew AN; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.; Zephyr J

Subjects: Drug Design* ; Drug Resistance, Viral*; Antiviral Agents/Antiviral Agents/Antiviral Agents/*chemistry

  • Source: MBio [mBio] 2020 Mar 31; Vol. 11 (2). Date of Electronic Publication: 2020 Mar 31.Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model:

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Academic Journal

Novel Pyrimidines as Antitubercular Agents.

  • Authors : Inoyama D; Department of Pharmacology, Physiology and Neuroscience, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.; Ruy V. Lourenço Center for the Study of Emerging and Re-Emerging Pathogens, Rutgers University, New Jersey Medical School, Newark, New Jersey, USA.

Subjects: Drug Design*; Antitubercular Agents/Antitubercular Agents/Antitubercular Agents/*chemical synthesis ; Mycobacterium tuberculosis/Mycobacterium tuberculosis/Mycobacterium tuberculosis/*drug effects

  • Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2018 Feb 23; Vol. 62 (3). Date of Electronic Publication: 2018 Feb 23 (Print Publication: 2018).Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model:

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Academic Journal

Discovery and Evaluation of Entry Inhibitors for SARS-CoV-2 and Its Emerging Variants.

  • Authors : Acharya A; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Centergrid.266813.8, Omaha, Nebraska, USA.; Pandey K

Subjects: COVID-19 Drug Treatment*; COVID-19/COVID-19/COVID-19/*virology ; SARS-CoV-2/SARS-CoV-2/SARS-CoV-2/*drug effectsSARS-CoV-2 variants

  • Source: Journal of virology [J Virol] 2021 Nov 23; Vol. 95 (24), pp. e0143721. Date of Electronic Publication: 2021 Sep 22.Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model:

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Academic Journal

Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.

  • Authors : Miao Y; Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA.; Tenor JL

Subjects: Drug Design*; Antifungal Agents/Antifungal Agents/Antifungal Agents/*chemistry ; Antifungal Agents/Antifungal Agents/Antifungal Agents/*metabolism

  • Source: MBio [mBio] 2017 Jul 25; Vol. 8 (4). Date of Electronic Publication: 2017 Jul 25.Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model:

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Academic Journal

Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs.

  • Authors : Gobeil SM; Department of Biochemistry, Duke Universitygrid.26009.3d, Durham, North Carolina, USA.; Department of Radiology, Duke Universitygrid.26009.3d, Durham, North Carolina, USA.

Subjects: Antifungal Agents/Antifungal Agents/Antifungal Agents/*chemistry ; Calcineurin/Calcineurin/Calcineurin/*chemistry ; Calcineurin Inhibitors/Calcineurin Inhibitors/Calcineurin Inhibitors/*chemistry Mucor circinelloides

  • Source: MBio [mBio] 2021 Dec 21; Vol. 12 (6), pp. e0300021. Date of Electronic Publication: 2021 Nov 23.Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model:

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Academic Journal

Semi-continuous Propagation of Influenza A Virus and Its Defective Interfering Particles: Analyzing the Dynamic Competition To Select Candidates for Antiviral Therapy.

  • Authors : Pelz L; Max Planck Institute for Dynamics of Complex Technical Systemsgrid.419517.f, Bioprocess Engineering, Magdeburg, Germany.; Rüdiger D

Subjects: Influenza A virus* ; RNA, Viral*; Antiviral Agents/Antiviral Agents/Antiviral Agents/*pharmacology

  • Source: Journal of virology [J Virol] 2021 Nov 23; Vol. 95 (24), pp. e0117421. Date of Electronic Publication: 2021 Sep 22.Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model:

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Academic Journal

Design and In Vivo Characterization of Immunoconjugates Targeting HIV gp160.

  • Authors : Pincus SH; Research Institute for Children, Children's Hospital, New Orleans, Louisiana, USA .; Department of Pediatrics and Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.

Subjects: Drug Design*; Anti-HIV Agents/Anti-HIV Agents/Anti-HIV Agents/*pharmacology ; HIV Envelope Protein gp160/HIV Envelope Protein gp160/HIV Envelope Protein gp160/*antagonists & inhibitors

  • Source: Journal of virology [J Virol] 2017 Jan 18; Vol. 91 (3). Date of Electronic Publication: 2017 Jan 18 (Print Publication: 2017).Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model:

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  • 1-10 of  232 results for ""Drug Design""