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A perspective on targeting non-structural proteins to combat neglected tropical diseases: Dengue, West Nile and Chikungunya viruses.

Authors : Bhakat, Soumendranath¹; Karubiu, Wilson¹; Jayaprakash, Venkatesan²

Subjects: *VIRAL nonstructural proteins; *DENGUE; *THERAPEUTICS

Source: European Journal of Medicinal Chemistry. Nov2014, Vol. 87, p677-702. 26p.

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Structure-based optimization and derivatization of 2-substituted quinolone-based non-nucleoside HCV NS5B inhibitors with submicromolar cellular replicon potency.

Authors : Cheng, Yu¹; Shen, Jian²; Peng, Run-Ze¹

Subjects: *HEPATITIS C treatment; *QUINOLONE antibacterial agents; *NUCLEOSIDES

Source: Bioorganic & Medicinal Chemistry Letters. Jun2016, Vol. 26 Issue 12, p2900-2906. 7p.

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Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase.

Authors : Benmansour, Fatiha^1,2; Eydoux, Cécilia^1,2; Querat, Gilles³

Subjects: *DENGUE; *THERAPEUTICS; *OXADIAZOLES

Source: European Journal of Medicinal Chemistry. Feb2016, Vol. 109, p146-156. 11p.

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Galectin-3 inhibits replication of porcine reproductive and respiratory syndrome virus by interacting with viral Nsp12 in vitro.

Authors : Li, Liwei^1,2; Zhou, Yanjun^1,2; Jiang, Yifeng^1,2

Subjects: *PORCINE reproductive & respiratory syndrome; *GALECTINS; *ANTIVIRAL agents

Source: Virus Research. Jul2018, Vol. 253, p87-91. 5p.

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Substituted tetracyclic indole core derivatives of HCV NS5A inhibitor MK-8742.

Authors : Yu, Wensheng¹ ; Zhou, Guowei¹; Coburn, Craig A.²

Subjects: *TETRACYCLINES; *PROLINE; *PHARMACOKINETICS

Source: Bioorganic & Medicinal Chemistry Letters. Oct2016, Vol. 26 Issue 19, p4851-4856. 6p.

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A perspective on targeting non-structural proteins to combat neglected tropical diseases: Dengue, West Nile and Chikungunya viruses.

Structure-based optimization and derivatization of 2-substituted quinolone-based non-nucleoside HCV NS5B inhibitors with submicromolar cellular replicon potency.

Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase.

Galectin-3 inhibits replication of porcine reproductive and respiratory syndrome virus by interacting with viral Nsp12 in vitro.

Substituted tetracyclic indole core derivatives of HCV NS5A inhibitor MK-8742.

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Search Results

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A perspective on targeting non-structural proteins to combat neglected tropical diseases: Dengue, West Nile and Chikungunya viruses.

Structure-based optimization and derivatization of 2-substituted quinolone-based non-nucleoside HCV NS5B inhibitors with submicromolar cellular replicon potency.

Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase.

Galectin-3 inhibits replication of porcine reproductive and respiratory syndrome virus by interacting with viral Nsp12 in vitro.

Substituted tetracyclic indole core derivatives of HCV NS5A inhibitor MK-8742.

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