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Antitubercular activity assessment of fluorinated chalcones, 2-aminopyridine-3-carbonitrile and 2-amino-4H-pyran-3-carbonitrile derivatives: In vitro, molecular docking and in-silico drug likeliness studies.

• Authors : Lagu SB; Pharmaceutical Chemistry Division, Adikavi Nannaya University College of Pharmaceutical Sciences, Adikavi Nannaya University, Tadepalligudem, Andhra Pradesh, India.; Yejella RP

Subjects: Chalcone* ; Chalcones*; Aminopyridines

• Source: PloS one [PLoS One] 2022 Jun 16; Vol. 17 (6), pp. e0265068. Date of Electronic Publication: 2022 Jun 16 (Print Publication: 2022).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection

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Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition.

• Authors : Silva G; Biotechnology Unit, University of Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil.; Marins M

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Chalcone/Chalcone/Chalcone/*pharmacology ; HSP40 Heat-Shock Proteins/HSP40 Heat-Shock Proteins/HSP40 Heat-Shock Proteins/*metabolism

• Source: PloS one [PLoS One] 2018 Aug 17; Vol. 13 (8), pp. e0202263. Date of Electronic Publication: 2018 Aug 17 (Print Publication: 2018).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection

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Chalcones identify cTXNPx as a potential antileishmanial drug target.

• Authors : Escrivani DO; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.; Department of Chemistry, Durham University, Science Laboratories, South Road, Durham, United Kingdom.

Subjects: Antiprotozoal Agents/Antiprotozoal Agents/Antiprotozoal Agents/*therapeutic use ; Chalcone/Chalcone/Chalcone/*metabolism ; Chalcone/Chalcone/Chalcone/*pharmacology

• Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2021 Nov 15; Vol. 15 (11), pp. e0009951. Date of Electronic Publication: 2021 Nov 15 (Print Publication: 2021).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection

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Fused ring effect on optical nonlinearity and structure property relationship of anthracenyl chalcone based push-pull chromophores.

• Authors : Zainuri DA; X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang, Malaysia.; Abdullah M

Subjects: Anthracenes/Anthracenes/Anthracenes/*chemistry ; Chalcones/Chalcones/Chalcones/*chemistry ; Fused-Ring Compounds/Fused-Ring Compounds/Fused-Ring Compounds/*chemistry

• Source: PloS one [PLoS One] 2021 Sep 28; Vol. 16 (9), pp. e0257808. Date of Electronic Publication: 2021 Sep 28 (Print Publication: 2021).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection

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Absence of genotoxic effects of the chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one) and its potential chemoprevention against DNA damage using in vitro and in vivo assays.

• Authors : Lima DC; Department of Genetics, Institute of Biological Sciences, Federal University of Goiás, Goiânia, GO, Brazil.; Vale CR

Subjects: Antimutagenic Agents/Antimutagenic Agents/Antimutagenic Agents/*pharmacology ; Chalcone/Chalcone/Chalcone/*pharmacology ; Chalcones/Chalcones/Chalcones/*pharmacology

• Source: PloS one [PLoS One] 2017 Feb 16; Vol. 12 (2), pp. e0171224. Date of Electronic Publication: 2017 Feb 16 (Print Publication: 2017).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection

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Tetramethoxychalcone, a chalcone derivative, suppresses proliferation, blocks cell cycle progression, and induces apoptosis of human ovarian cancer cells.

• Authors : Qi Z; Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.

Subjects: Apoptosis/Apoptosis/Apoptosis/*drug effects ; Cell Cycle/Cell Cycle/Cell Cycle/*drug effects ; Chalcone/Chalcone/Chalcone/*pharmacology

• Source: PloS one [PLoS One] 2014 Sep 02; Vol. 9 (9), pp. e106206. Date of Electronic Publication: 2014 Sep 02 (Print Publication: 2014).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection

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In vitro selective cytotoxicity of the dietary chalcone cardamonin (CD) on melanoma compared to healthy cells is mediated by apoptosis.

• Authors : Berning L; Institute of Biochemistry and Molecular Biology I, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.; Scharf L

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Apoptosis/Apoptosis/Apoptosis/*drug effects ; Chalcones/Chalcones/Chalcones/*pharmacology

• Source: PloS one [PLoS One] 2019 Sep 25; Vol. 14 (9), pp. e0222267. Date of Electronic Publication: 2019 Sep 25 (Print Publication: 2019).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection

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A Hybrid Chalcone Combining the Trimethoxyphenyl and Isatinyl Groups Targets Multiple Oncogenic Proteins and Pathways in Hepatocellular Carcinoma Cells.

• Authors : Cao L; Department of Cell Biology, School of Basic Medical Sciences, Peking University, Beijing, China.; Zhang L

Subjects: Molecular Targeted Therapy*; Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/Carcinoma, Hepatocellular/*pathology ; Chalcone/Chalcone/Chalcone/*chemistry

• Source: PloS one [PLoS One] 2016 Aug 15; Vol. 11 (8), pp. e0161025. Date of Electronic Publication: 2016 Aug 15 (Print Publication: 2016).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection

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Dual Inhibition of Topoisomerase II and Tyrosine Kinases by the Novel Bis-Fluoroquinolone Chalcone-Like Derivative HMNE3 in Human Pancreatic Cancer Cells.

• Authors : Ma YC; Clinical Medical Institute of Luohe Medical College, Luohe, Henan, P.R. China.; The First Affiliated Hospital of Luohe Medical College, Luohe, Henan, P.R. China.

Subjects: Chalcone/Chalcone/Chalcone/*chemistry ; Ciprofloxacin/Ciprofloxacin/Ciprofloxacin/*analogs & derivatives ; DNA Topoisomerases, Type II/DNA Topoisomerases, Type II/DNA Topoisomerases, Type II/*metabolism

• Source: PloS one [PLoS One] 2016 Oct 19; Vol. 11 (10), pp. e0162821. Date of Electronic Publication: 2016 Oct 19 (Print Publication: 2016).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection

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Expression of Concern: Dual Inhibition of Topoisomerase II and Tyrosine Kinases by the Novel Bis-Fluoroquinolone Chalcone-Like Derivative HMNE3 in Human Pancreatic Cancer Cells

• Source: PLoS ONE. November 15, 2023, Vol. 18 Issue 11, e0294622

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