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Academic Journal

RuBi-Ruxolitinib: A Photoreleasable Antitumor JAK Inhibitor.

  • Authors : Rafic E; Departamento de Química Inorgánica, Analítica y Química Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, INQUIMAE, CONICET, Buenos Aires C1428EHA, Argentina.; Ma C

Subjects: Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/pharmacology ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/chemistry ; Antineoplastic Agents*/Antineoplastic Agents*/Antineoplastic Agents*/chemical synthesis

  • Source: Journal of the American Chemical Society [J Am Chem Soc] 2024 May 15; Vol. 146 (19), pp. 13317-13325. Date of Electronic Publication: 2024 May 03.Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

A Novel Tetramethylpyrazine Chalcone Hybrid- HCTMPPK, as a Potential Anti-Lung Cancer Agent by Downregulating MELK.

  • Authors : Ma Y; Qingdao Key Laboratory of Common Diseases, Qingdao Municipal Hospital, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong, 260071, People's Republic of China.; Department of Respiratory and Critical Care Medicine, Qingdao Municipal Hospital, University of Health and Rehabilitation Sciences, Qingdao, 266071, People's Republic of China.

Subjects: Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/drug therapy ; Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/pathology ; Pyrazines*/Pyrazines*/Pyrazines*/pharmacology

  • Source: Drug design, development and therapy [Drug Des Devel Ther] 2024 May 07; Vol. 18, pp. 1531-1546. Date of Electronic Publication: 2024 May 07 (Print Publication: 2024).Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN:

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Academic Journal

Discovery of potent and novel dual NAMPT/BRD4 inhibitors for efficient treatment of hepatocellular carcinoma.

  • Authors : Yin C; School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China.; Jia S

Subjects: Nicotinamide Phosphoribosyltransferase*/Nicotinamide Phosphoribosyltransferase*/Nicotinamide Phosphoribosyltransferase*/antagonists & inhibitors ; Nicotinamide Phosphoribosyltransferase*/Nicotinamide Phosphoribosyltransferase*/Nicotinamide Phosphoribosyltransferase*/metabolism ; Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/Carcinoma, Hepatocellular*/drug therapy

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2024 May 05; Vol. 271, pp. 116444. Date of Electronic Publication: 2024 Apr 26.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Effective Anticancer Potential of a New Sulfonamide as a Carbonic Anhydrase IX Inhibitor Against Aggressive Tumors.

  • Authors : Koyuncu I; Department of Medical Biochemistry, Faculty of Medicine, Harran University, Sanliurfa, Turkey Tel.; Temiz E

Subjects: Carbonic Anhydrase IX*/Carbonic Anhydrase IX*/Carbonic Anhydrase IX*/antagonists & inhibitors ; Carbonic Anhydrase IX*/Carbonic Anhydrase IX*/Carbonic Anhydrase IX*/metabolism ; Sulfonamides*/Sulfonamides*/Sulfonamides*/pharmacology

  • Source: ChemMedChem [ChemMedChem] 2024 May 02; Vol. 19 (9), pp. e202300680. Date of Electronic Publication: 2024 Feb 27.Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187

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Academic Journal

Semi-synthesized anticancer theobromine derivatives targeting VEGFR-2: in silico and in vitro evaluations.

  • Authors : Dahab MA; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.; Mahdy HA

Subjects: Vascular Endothelial Growth Factor Receptor-2*/Vascular Endothelial Growth Factor Receptor-2*/Vascular Endothelial Growth Factor Receptor-2*/antagonists & inhibitors ; Vascular Endothelial Growth Factor Receptor-2*/Vascular Endothelial Growth Factor Receptor-2*/Vascular Endothelial Growth Factor Receptor-2*/metabolism ; Molecular Docking Simulation*

  • Source: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2024 May; Vol. 42 (8), pp. 4214-4233. Date of Electronic Publication: 2023 Jun 01.Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Quinazoline-chalcone hybrids as HDAC/EGFR dual inhibitors: Design, synthesis, mechanistic, and in-silico studies of potential anticancer activity against multiple myeloma.

  • Authors : Mansour MA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Nahda University in Beni-Suef (NUB), Beni-Suef, Egypt.; AboulMagd AM

Subjects: Histone Deacetylase Inhibitors*/Histone Deacetylase Inhibitors*/Histone Deacetylase Inhibitors*/pharmacology ; Histone Deacetylase Inhibitors*/Histone Deacetylase Inhibitors*/Histone Deacetylase Inhibitors*/chemical synthesis ; Histone Deacetylase Inhibitors*/Histone Deacetylase Inhibitors*/Histone Deacetylase Inhibitors*/chemistry

  • Source: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 May; Vol. 357 (5), pp. e2300626. Date of Electronic Publication: 2024 Jan 31.Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Rational design and synthesis of 2,4-dichloro-6-methyl pyrimidine derivatives as potential selective EGFR T790M/L858R inhibitors for the treatment of non-small cell lung cancer.

  • Authors : Duan L; Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, Jiangxi Science & Technology Normal University, Nanchang, Jiangxi, China.; Chu C

Subjects: Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/drug therapy ; Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/pathology ; ErbB Receptors*/ErbB Receptors*/ErbB Receptors*/antagonists & inhibitors

  • Source: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 May; Vol. 357 (5), pp. e2300736. Date of Electronic Publication: 2024 Feb 21.Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Design, Synthesis, and Biological Evaluation of Novel Quinazoline Derivatives Possessing a Trifluoromethyl Moiety as Potential Antitumor Agents.

  • Authors : Chen M; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China.; Natural Products Research Center of Guizhou Province, Guiyang, 550014, China.

Subjects: Quinazolines*/Quinazolines*/Quinazolines*/pharmacology ; Quinazolines*/Quinazolines*/Quinazolines*/chemistry ; Quinazolines*/Quinazolines*/Quinazolines*/chemical synthesis

  • Source: Chemistry & biodiversity [Chem Biodivers] 2024 May; Vol. 21 (5), pp. e202301776. Date of Electronic Publication: 2024 Apr 11.Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Anticancer Effects of Mitoquinone via Cell Cycle Arrest and Apoptosis in Canine Mammary Gland Tumor Cells.

  • Authors : Lee R; Department of Livestock, Korea National University of Agriculture and Fisheries, Jeonju-si 54874, Republic of Korea.; Department of Animal Biotechnology, College of Life Science, Sangji University, Wonju-si 26339, Republic of Korea.

Subjects: Apoptosis*/Apoptosis*/Apoptosis*/drug effects ; Mammary Neoplasms, Animal*/Mammary Neoplasms, Animal*/Mammary Neoplasms, Animal*/drug therapy ; Mammary Neoplasms, Animal*/Mammary Neoplasms, Animal*/Mammary Neoplasms, Animal*/pathology

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 30; Vol. 25 (9). Date of Electronic Publication: 2024 Apr 30.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Discovery of gefitinib-1,2,3-triazole derivatives against lung cancer via inducing apoptosis and inhibiting the colony formation.

  • Authors : Gao E; School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, 453000, China. .; State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China. .

Subjects: Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/drug therapy ; Lung Neoplasms*/Lung Neoplasms*/Lung Neoplasms*/pathology ; Gefitinib*/Gefitinib*/Gefitinib*/pharmacology

  • Source: Scientific reports [Sci Rep] 2024 Apr 22; Vol. 14 (1), pp. 9223. Date of Electronic Publication: 2024 Apr 22.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  79,320 results for ""Cell Proliferation""