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Academic Journal

Rheostats, toggles, and neutrals, Oh my! A new framework for understanding how amino acid changes modulate protein function.

  • Authors : Swint-Kruse L; Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA. Electronic address: .; Fenton AW

Subjects: Amino Acid Substitution* ; Amino Acids*/Amino Acids*/Amino Acids*/genetics ; Amino Acids*/Amino Acids*/Amino Acids*/metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2024 Mar; Vol. 300 (3), pp. 105736. Date of Electronic Publication: 2024 Feb 08.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Sex-biased genetic regulation of inflammatory proteins in the Dutch population.

  • Authors : Boahen CK; Department of Internal Medicine and Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, 6525 HP, the Netherlands.; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, 6525 HP, the Netherlands.

Subjects: Proteins*/Proteins*/Proteins*/genetics ; Quantitative Trait Loci*; Male

  • Source: BMC genomics [BMC Genomics] 2024 Feb 08; Vol. 25 (1), pp. 154. Date of Electronic Publication: 2024 Feb 08.Publisher: BioMed Central Country of Publication: England NLM ID: 100965258 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2164

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Academic Journal

Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation.

  • Authors : Lee CY; Institute of Molecular Biology (IMB) gGmbH, 55128, Mainz, Germany.; Hubrich D

Subjects: Proteins*/Proteins*/Proteins*/metabolism ; Carrier Proteins*; Humans

  • Source: Molecular systems biology [Mol Syst Biol] 2024 Feb; Vol. 20 (2), pp. 75-97. Date of Electronic Publication: 2024 Jan 15.Publisher: Wiley Blackwell Country of Publication: England NLM ID: 101235389 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling.

  • Authors : Hancock-Cerutti W; Department of Neuroscience, Yale University School of Medicine, New Haven, CT.; Department of Cell Biology, Yale University School of Medicine, New Haven, CT.

Subjects: DNA, Mitochondrial*/DNA, Mitochondrial*/DNA, Mitochondrial*/genetics ; Endoplasmic Reticulum*/Endoplasmic Reticulum*/Endoplasmic Reticulum*/metabolism ; Membrane Proteins*/Membrane Proteins*/Membrane Proteins*/metabolism

  • Source: The Journal of cell biology [J Cell Biol] 2022 Jul 04; Vol. 221 (7). Date of Electronic Publication: 2022 Jun 03.Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 0375356 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Reconstitution of purified membrane protein dimers in lipid nanodiscs with defined stoichiometry and orientation using a split GFP tether.

  • Authors : Bruguera ES; Departments of Molecular & Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, California, USA.; Mahoney JP

Subjects: Chemistry Techniques, Analytical*/Chemistry Techniques, Analytical*/Chemistry Techniques, Analytical*/methods ; Membrane Proteins*/Membrane Proteins*/Membrane Proteins*/chemistry ; Membrane Proteins*/Membrane Proteins*/Membrane Proteins*/genetics

  • Source: The Journal of biological chemistry [J Biol Chem] 2022 Apr; Vol. 298 (4), pp. 101628. Date of Electronic Publication: 2022 Jan 22.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Optimizing purification of the peripheral membrane protein FAM92A1 fused to a modified spidroin tag.

  • Authors : Wang Z; Department of Biomedical Engineering and Health Systems, Royal Technical Institute (KTH), Hälsovägen 11C, 141 2 Huddinge, Sweden.; Mim C

Subjects: Fibroins/Fibroins/Fibroins/*genetics ; Membrane Proteins/Membrane Proteins/Membrane Proteins/*genetics ; Proteins/Proteins/Proteins/*genetics

  • Source: Protein expression and purification [Protein Expr Purif] 2022 Jan; Vol. 189, pp. 105992. Date of Electronic Publication: 2021 Oct 11.Publisher: Academic Press Country of Publication: United States NLM ID: 9101496 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.

  • Authors : Georgiadi A; Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany. .; Joint Heidelberg-IDC Transnational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany. .

Subjects: Adipose Tissue, White/Adipose Tissue, White/Adipose Tissue, White/*metabolism ; Membrane Proteins/Membrane Proteins/Membrane Proteins/*metabolism ; Prediabetic State/Prediabetic State/Prediabetic State/*metabolism

  • Source: Nature communications [Nat Commun] 2021 May 20; Vol. 12 (1), pp. 2999. Date of Electronic Publication: 2021 May 20.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties.

  • Authors : Dooley K; Codiak BioSciences, Cambridge, MA 02140, USA. Electronic address: .; McConnell RE

Subjects: Extracellular Vesicles/Extracellular Vesicles/Extracellular Vesicles/*transplantation ; Membrane Proteins/Membrane Proteins/Membrane Proteins/*metabolism ; Neoplasm Proteins/Neoplasm Proteins/Neoplasm Proteins/*metabolism

  • Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2021 May 05; Vol. 29 (5), pp. 1729-1743. Date of Electronic Publication: 2021 Jan 21.Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Oa AEP1-mediated PNA-protein conjugation enables erasable imaging of membrane proteins.

  • Authors : Lu Z; Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu, 210023, P. R. China. .; State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, Jiangsu, 210023, P. R. China.

Subjects: Nanostructures*/Nanostructures*/Nanostructures*/chemistry ; Peptide Nucleic Acids*/Peptide Nucleic Acids*/Peptide Nucleic Acids*/chemistry; Proteins/Proteins/Proteins/*metabolism

  • Source: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2022 Jul 26; Vol. 58 (60), pp. 8448-8451. Date of Electronic Publication: 2022 Jul 26.Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

In situ architecture of the lipid transport protein VPS13C at ER-lysosome membrane contacts.

  • Authors : Cai S; Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510.; Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510.

Subjects: Endoplasmic Reticulum*/Endoplasmic Reticulum*/Endoplasmic Reticulum*/chemistry ; Lipid Metabolism* ; Proteins*/Proteins*/Proteins*/chemistry

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Jul 19; Vol. 119 (29), pp. e2203769119. Date of Electronic Publication: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet

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