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Focused ultrasound gene delivery for the treatment of neurological disorders.

• Authors : Kofoed RH; Department of Neurosurgery, Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 165, 8200 Aarhus N, Denmark; Center for Experimental Neuroscience (CENSE), Department of Neurosurgery, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, 8200 Aarhus N, Denmark

Subjects: Blood-Brain Barrier*/Blood-Brain Barrier*/Blood-Brain Barrier*/metabolism ; Brain Diseases*; Humans

• Source: Trends in molecular medicine [Trends Mol Med] 2024 Mar; Vol. 30 (3), pp. 263-277. Date of Electronic Publication: 2024 Jan 11.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 100966035 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Science around the world.

• Authors : Burton JP; Department of Microbiology and Immunology, Western University, London, Ontario, Canada; Canadian Centre for Human Microbiome and Probiotics Research, Lawson Health Research Institute, London, Ontario, Canada

Subjects: Science*; Humans

• Source: Trends in molecular medicine [Trends Mol Med] 2024 Mar; Vol. 30 (3), pp. 197-199. Date of Electronic Publication: 2024 Feb 23.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 100966035 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Using focused ultrasound to modulate microglial structure and function.

• Authors : Grewal S; Department of Bioengineering, Imperial College London, London, United Kingdom.; Department of Brain Sciences, Imperial College London, London, United Kingdom.

• Source: Frontiers in cellular neuroscience [Front Cell Neurosci] 2023 Dec 18; Vol. 17, pp. 1290628. Date of Electronic Publication: 2023 Dec 18 (Print Publication: 2023).Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477935 Publication Model: eCollection Cited Medium: Print

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Sonoselective delivery using ultrasound and microbubbles combined with intravenous rAAV9 CLDN5-GFP does not increase endothelial gene expression.

• Authors : Kofoed RH; Biological Sciences, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, Canada. .; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. .

Subjects: Ultrasonography* ; Microbubbles*/Microbubbles*/Microbubbles*/therapeutic use ; Dependovirus*/Dependovirus*/Dependovirus*/genetics

• Source: Gene therapy [Gene Ther] 2023 Dec; Vol. 30 (12), pp. 807-811. Date of Electronic Publication: 2023 Feb 13.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9421525 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Efficacy of gene delivery to the brain using AAV and ultrasound depends on serotypes and brain areas.

• Authors : Kofoed RH; Biological Sciences, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address: .

Subjects: Genetic Vectors* ; Dependovirus*/Dependovirus*/Dependovirus*/genetics; Animals

• Source: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2022 Nov; Vol. 351, pp. 667-680. Date of Electronic Publication: 2022 Oct 06.Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet

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The engineered AAV2-HBKO promotes non-invasive gene delivery to large brain regions beyond ultrasound targeted sites.

• Authors : Kofoed RH; Biological Sciences, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, 2075 Bayview Ave., Toronto, ON M4N 3M5, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Temerty Faculty of Medicine, 1 King's College Cir., Toronto, ON M5S 1A8, Canada.

• Source: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2022 Sep 26; Vol. 27, pp. 167-184. Date of Electronic Publication: 2022 Sep 26 (Print Publication: Publisher: Cell Press Country of Publication: United States NLM ID: 101624857 Publication Model: eCollection Cited Medium: Print ISSN: 2329-0501

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Viral alpha-synuclein knockdown prevents spreading synucleinopathy.

• Authors : Menon S; Tanz Centre for Research in Neurodegenerative Diseases, Toronto, ON M5T 0S8, Canada.; Kofoed RH

• Source: Brain communications [Brain Commun] 2021 Oct 22; Vol. 3 (4), pp. fcab247. Date of Electronic Publication: 2021 Oct 22 (Print Publication: 2021).Publisher: Oxford University Press Country of Publication: England NLM ID: 101755125 Publication Model: eCollection Cited Medium: Internet ISSN:

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Transgene distribution and immune response after ultrasound delivery of rAAV9 and PHP.B to the brain in a mouse model of amyloidosis.

• Authors : Kofoed RH; Biological Sciences, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada.; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.

• Source: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2021 Oct 08; Vol. 23, pp. 390-405. Date of Electronic Publication: 2021 Oct 08 (Print Publication: Publisher: Cell Press Country of Publication: United States NLM ID: 101624857 Publication Model: eCollection Cited Medium: Print ISSN: 2329-0501

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Systemic AAV6-synapsin-GFP administration results in lower liver biodistribution, compared to AAV1&2 and AAV9, with neuronal expression following ultrasound-mediated brain delivery.

• Authors : Weber-Adrian D; Faculty of Health Sciences, School of Medicine, Queen's University, Kingston, ON, Canada.; Biological Sciences, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, Canada.

Subjects: Brain/Brain/Brain/*drug effects ; Brain/Brain/Brain/*metabolism ; Dependovirus/Dependovirus/Dependovirus/*genetics

• Source: Scientific reports [Sci Rep] 2021 Jan 21; Vol. 11 (1), pp. 1934. Date of Electronic Publication: 2021 Jan 21.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN:

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PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation.

• Authors : Reimer L; Danish Research Institute of Translational Neuroscience - DANDRITE, Aarhus University, Aarhus, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark.

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*metabolism ; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*pathology ; eIF-2 Kinase/eIF-2 Kinase/eIF-2 Kinase/*metabolism

• Source: Brain pathology (Zurich, Switzerland) [Brain Pathol] 2021 Jan; Vol. 31 (1), pp. 103-119. Date of Electronic Publication: 2020 Aug 06.Publisher: International Society of Neuropathology Country of Publication: Switzerland NLM ID: 9216781 Publication Model: Print-Electronic Cited Medium:

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