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Academic Journal

WLB-87848, a Selective σ 1 Receptor Agonist, with an Unusually Positioned NH Group as Positive Ionizable Moiety and Showing Neuroprotective Activity.

  • Authors : Christmann U; Welab Barcelona, Parc Científic Barcelona, C/Baldiri Reixac 4-8, Barcelona 08028, Spain.; Garriga L

Subjects: Receptors, sigma*/Receptors, sigma*/Receptors, sigma*/agonists ; Receptors, sigma*/Receptors, sigma*/Receptors, sigma*/metabolism ; Neuroprotective Agents*/Neuroprotective Agents*/Neuroprotective Agents*/pharmacology

  • Source: Journal of medicinal chemistry [J Med Chem] 2024 Jun 13; Vol. 67 (11), pp. 9150-9164. Date of Electronic Publication: 2024 May 16.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Sigma Receptor Ligands Are Potent Antiprion Compounds that Act Independently of Sigma Receptor Binding.

  • Authors : Mercer RCC; Department of Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts 02118, United States.; Le NTT

Subjects: Receptors, sigma*/Receptors, sigma*/Receptors, sigma*/metabolism ; Receptors, sigma*/Receptors, sigma*/Receptors, sigma*/drug effects ; Prion Diseases*/Prion Diseases*/Prion Diseases*/drug therapy

  • Source: ACS chemical neuroscience [ACS Chem Neurosci] 2024 Jun 05; Vol. 15 (11), pp. 2265-2282. Date of Electronic Publication: 2024 May 14.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Modulation of the Blood-Brain Barrier by Sigma-1R Activation.

  • Authors : Brailoiu E; Center for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.; Department of Neural Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.

Subjects: Receptors, sigma*/Receptors, sigma*/Receptors, sigma*/metabolism ; Receptors, sigma*/Receptors, sigma*/Receptors, sigma*/agonists ; Blood-Brain Barrier*/Blood-Brain Barrier*/Blood-Brain Barrier*/metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 May 09; Vol. 25 (10). Date of Electronic Publication: 2024 May 09.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Cytotoxic sigma-2 ligands trigger cancer cell death via cholesterol-induced-ER-stress.

  • Authors : Takchi R; Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.; Prudner BC

Subjects: Cholesterol*/Cholesterol*/Cholesterol*/metabolism ; Receptors, sigma*/Receptors, sigma*/Receptors, sigma*/metabolism ; Receptors, sigma*/Receptors, sigma*/Receptors, sigma*/genetics

  • Source: Cell death & disease [Cell Death Dis] 2024 May 02; Vol. 15 (5), pp. 309. Date of Electronic Publication: 2024 May 02.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

N, N-Dimethyltryptamine, a natural hallucinogen, ameliorates Alzheimer's disease by restoring neuronal Sigma-1 receptor-mediated endoplasmic reticulum-mitochondria crosstalk.

  • Authors : Cheng D; Department of Chinese Medicine, The University of Hong Kong-Shenzhen Hospital (HKU-SZH), Shenzhen, China.; School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Subjects: Receptors, sigma*/Receptors, sigma*/Receptors, sigma*/metabolism ; Receptors, sigma*/Receptors, sigma*/Receptors, sigma*/agonists ; Sigma-1 Receptor*

  • Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2024 May 01; Vol. 16 (1), pp. 95. Date of Electronic Publication: 2024 May 01.Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Antinociceptive effect of LMH-2, a new sigma-1 receptor antagonist analog of haloperidol, on the neuropathic pain of diabetic mice.

  • Authors : Ventura-Martínez R; Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Av Universidad No. 3000, Col. Ciudad Universitaria, Alcaldía Coyoacán, Ciudad de México 04510, Mexico. Electronic address: .; Ángeles-López GE

Subjects: Receptors, sigma*/Receptors, sigma*/Receptors, sigma*/antagonists & inhibitors ; Receptors, sigma*/Receptors, sigma*/Receptors, sigma*/metabolism ; Haloperidol*/Haloperidol*/Haloperidol*/pharmacology

  • Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 May; Vol. 174, pp. 116524. Date of Electronic Publication: 2024 Apr 03.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Structural determinants of the direct inhibition of GIRK channels by Sigma-1 receptor antagonist.

  • Authors : Liu C; Division of Biophysics and Neurobiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan; Program of Physiological Sciences, Field of Life Science, Department of Advanced Studies, SOKENDAI (The Graduate University for Advanced Studies), Hayama, Japan. Electronic address: .

Subjects: G Protein-Coupled Inwardly-Rectifying Potassium Channels*/G Protein-Coupled Inwardly-Rectifying Potassium Channels*/G Protein-Coupled Inwardly-Rectifying Potassium Channels*/metabolism ; G Protein-Coupled Inwardly-Rectifying Potassium Channels*/G Protein-Coupled Inwardly-Rectifying Potassium Channels*/G Protein-Coupled Inwardly-Rectifying Potassium Channels*/genetics ; G Protein-Coupled Inwardly-Rectifying Potassium Channels*/G Protein-Coupled Inwardly-Rectifying Potassium Channels*/G Protein-Coupled Inwardly-Rectifying Potassium Channels*/chemistry

  • Source: The Journal of biological chemistry [J Biol Chem] 2024 May; Vol. 300 (5), pp. 107219. Date of Electronic Publication: 2024 Mar 24.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Academic Journal

Sigma-1 Receptor Inhibition Reduces Mechanical Allodynia and Modulate Neuroinflammation in Chronic Neuropathic Pain.

  • Authors : Denaro S; Section of Physiology, Department of Biomedical and Biotechnological Sciences, University of Catania, 95123, Catania, Italy.; Pasquinucci L

Subjects: Receptors, sigma*/Receptors, sigma*/Receptors, sigma*/metabolism ; Receptors, sigma*/Receptors, sigma*/Receptors, sigma*/antagonists & inhibitors ; Sigma-1 Receptor*

  • Source: Molecular neurobiology [Mol Neurobiol] 2024 May; Vol. 61 (5), pp. 2672-2685. Date of Electronic Publication: 2023 Nov 03.Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Unraveling the CLCC1 interactome: Impact of the Asp25Glu variant and its interaction with SigmaR1 at the Mitochondrial-Associated ER Membrane (MAM).

  • Authors : D'Atri I; School of Physiology, Pharmacology and Neuroscience, University of Bristol, BS8 1TD, United Kingdom; University of Exeter Medical School, University of Exeter, Exeter, United Kingdom.

Subjects: Endoplasmic Reticulum*/Endoplasmic Reticulum*/Endoplasmic Reticulum*/metabolism ; Receptors, sigma*/Receptors, sigma*/Receptors, sigma*/metabolism ; Receptors, sigma*/Receptors, sigma*/Receptors, sigma*/genetics

  • Source: Neuroscience letters [Neurosci Lett] 2024 May 01; Vol. 830, pp. 137778. Date of Electronic Publication: 2024 Apr 15.Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

CGI1746 targets σ 1 R to modulate ferroptosis through mitochondria-associated membranes.

  • Authors : Zhang Z; Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Zhou H

Subjects: Ferroptosis*/Ferroptosis*/Ferroptosis*/drug effects ; Receptors, sigma*/Receptors, sigma*/Receptors, sigma*/metabolism ; Sigma-1 Receptor*

  • Source: Nature chemical biology [Nat Chem Biol] 2024 Jun; Vol. 20 (6), pp. 699-709. Date of Electronic Publication: 2024 Jan 11.Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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  • 1-10 of  23,788 results for ""Receptors, sigma""