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Dimer Peptide Ligands of Vascular Endothelial Growth Factor: Optimizing Linker Length for High Affinity and Antiangiogenic Activity.

• Authors : Ye X; CiTCoM, UMR CNRS 8038, U1268 INSERM, Université Paris Cité, Faculté de Santé, UFR de Pharmacie, 4 av. de l'Observatoire, 75006 Paris, France.; Gaucher JF

Subjects: Vascular Endothelial Growth Factor A*/Vascular Endothelial Growth Factor A*/Vascular Endothelial Growth Factor A*/metabolism ; Peptides*/Peptides*/Peptides*/chemistry; Humans

• Source: Journal of medicinal chemistry [J Med Chem] 2023 Jul 27; Vol. 66 (14), pp. 9753-9765. Date of Electronic Publication: 2023 Jul 06.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet

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Structural and ITC Characterization of Peptide-Protein Binding: Thermodynamic Consequences of Cyclization Constraints, a Case Study on Vascular Endothelial Growth Factor Ligands.

• Authors : Gaucher JF; CiTCoM, UMR CNRS 8038, Université Paris Cité, Faculté de Santé, UFR de Pharmacie, 4 av. de l'Observatoire, 75006, Paris, France.; Reille-Seroussi M

Subjects: Peptides*/Peptides*/Peptides*/chemistry ; Vascular Endothelial Growth Factor A*; Calorimetry/Calorimetry/Calorimetry/methods

• Source: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2022 Aug 26; Vol. 28 (48), pp. e202200465. Date of Electronic Publication: 2022 Jul 07.Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9513783 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3765

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A Structural Overview of Vascular Endothelial Growth Factors Pharmacological Ligands: From Macromolecules to Designed Peptidomimetics.

• Authors : Ye X; Faculté de Pharmacie de Paris, Université de Paris, CiTCoM, 8038 CNRS, U 1268 INSERM, 75006 Paris, France.; Gaucher JF

Subjects: Angiogenesis Inhibitors*/Angiogenesis Inhibitors*/Angiogenesis Inhibitors*/chemistry ; Angiogenesis Inhibitors*/Angiogenesis Inhibitors*/Angiogenesis Inhibitors*/therapeutic use ; Macular Degeneration*/Macular Degeneration*/Macular Degeneration*/drug therapy

• Source: Molecules (Basel, Switzerland) [Molecules] 2021 Nov 09; Vol. 26 (22). Date of Electronic Publication: 2021 Nov 09.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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VEGF (Vascular Endothelial Growth Factor) Functionalized Magnetic Beads in a Microfluidic Device to Improve the Angiogenic Balance in Preeclampsia.

• Authors : Trapiella-Alfonso L; From the UMR 8638 (L.T.-A., K.P., L.H., M.V., N.G.-E.), CNRS, Université Paris Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, Sorbonne Paris Cité, Paris, France.; Alexandre L

Subjects: Lab-On-A-Chip Devices*; Pre-Eclampsia/Pre-Eclampsia/Pre-Eclampsia/*therapy ; Vascular Endothelial Growth Factor A/Vascular Endothelial Growth Factor A/Vascular Endothelial Growth Factor A/*pharmacology

• Source: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2019 Jul; Vol. 74 (1), pp. 145-153. Date of Electronic Publication: 2019 May 13.Publisher: Lippincott, Williams & Wilkins Country of Publication: United States NLM ID: 7906255 Publication Model: Print-Electronic Cited Medium:

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VEGFR1 domain 2 covalent labeling with horseradish peroxidase: Development of a displacement assay on VEGF.

• Authors : Reille-Seroussi M; UMR 8638 CNRS Université Paris Descartes, Faculté de Pharmacie de Paris, Sorbonne Paris Cité, 4 Avenue de l'Observatoire, Paris 75006, France.; Gaucher JF

Subjects: Biological Assay/Biological Assay/Biological Assay/*methods ; Horseradish Peroxidase/Horseradish Peroxidase/Horseradish Peroxidase/*metabolism ; Vascular Endothelial Growth Factor A/Vascular Endothelial Growth Factor A/Vascular Endothelial Growth Factor A/*metabolism

• Source: Analytical biochemistry [Anal Biochem] 2017 Aug 01; Vol. 530, pp. 107-112. Date of Electronic Publication: 2017 May 03.Publisher: Elsevier Country of Publication: United States NLM ID: 0370535 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Biophysical Studies of the Induced Dimerization of Human VEGF Receptor 1 Binding Domain by Divalent Metals Competing with VEGF-A.

• Authors : Gaucher JF; UMR 8015 CNRS - Université Paris Descartes, Faculté de Pharmacie, Sorbonne Paris Cité, Paris, France.; Reille-Seroussi M

Subjects: Molecular Docking Simulation* ; Protein Multimerization*; Cations, Divalent/Cations, Divalent/Cations, Divalent/*pharmacology

• Source: PloS one [PLoS One] 2016 Dec 12; Vol. 11 (12), pp. e0167755. Date of Electronic Publication: 2016 Dec 12 (Print Publication: 2016).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet

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Vascular Endothelial Growth Factor Peptide Ligands Explored by Competition Assay and Isothermal Titration Calorimetry.

• Authors : Reille-Seroussi M; Gaucher JF; Desole C

Subjects: Calorimetry* ; Competitive Bidding* ; Drug Design*

• Source: Biochemistry [Biochemistry] 2015 Aug 25; Vol. 54 (33), pp. 5147-56. Date of Electronic Publication: 2015 Aug 13.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet

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Interactions of isolated C-terminal fragments of neural Wiskott-Aldrich syndrome protein (N-WASP) with actin and Arp2/3 complex.

• Authors : Gaucher JF; Laboratoire de Cristallographie et RMN Biologiques CNRS UMR 8015, Faculté de Pharmacie, Université Paris Descartes, Sorbonne Paris Cité, 4 avenue de l'Observatoire, 75006 Paris, France.; Maugé C

Subjects: Actin-Related Protein 2-3 Complex*/Actin-Related Protein 2-3 Complex*/Actin-Related Protein 2-3 Complex*/chemistry ; Actin-Related Protein 2-3 Complex*/Actin-Related Protein 2-3 Complex*/Actin-Related Protein 2-3 Complex*/metabolism ; Actins*/Actins*/Actins*/chemistry

• Source: The Journal of biological chemistry [J Biol Chem] 2012 Oct 05; Vol. 287 (41), pp. 34646-59. Date of Electronic Publication: 2012 Jul 30.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication

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Targeting the proangiogenic VEGF-VEGFR protein-protein interface with drug-like compounds by in silico and in vitro screening.

• Authors : Gautier B; Université Paris Descartes, CNRS UMR 8601, UFR biomédicale, 75006 Paris, France.; Miteva MA

Subjects: Receptors, Vascular Endothelial Growth Factor/Receptors, Vascular Endothelial Growth Factor/Receptors, Vascular Endothelial Growth Factor/*metabolism ; Vascular Endothelial Growth Factor A/Vascular Endothelial Growth Factor A/Vascular Endothelial Growth Factor A/*metabolism; Angiogenesis Inhibitors/Angiogenesis Inhibitors/Angiogenesis Inhibitors/pharmacology

• Source: Chemistry & biology [Chem Biol] 2011 Dec 23; Vol. 18 (12), pp. 1631-9.Publisher: Elsevier Country of Publication: United States NLM ID: 9500160 Publication Model: Print Cited Medium: Internet ISSN: 1879-1301

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Arp2/3 controls the motile behavior of N-WASP-functionalized GUVs and modulates N-WASP surface distribution by mediating transient links with actin filaments.

• Authors : Delatour V; Cytoskeleton Dynamics and Motility, Laboratoire d'Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France.; Helfer E

Subjects: Actin Cytoskeleton/Actin Cytoskeleton/Actin Cytoskeleton/*chemistry ; Actin-Related Protein 2-3 Complex/Actin-Related Protein 2-3 Complex/Actin-Related Protein 2-3 Complex/*chemistry ; Actin-Related Protein 2-3 Complex/Actin-Related Protein 2-3 Complex/Actin-Related Protein 2-3 Complex/*ultrastructure

• Source: Biophysical journal [Biophys J] 2008 Jun; Vol. 94 (12), pp. 4890-905. Date of Electronic Publication: 2008 Mar 07.Publisher: Cell Press Country of Publication: United States NLM ID: 0370626 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Crystal structure of apo-calmodulin bound to the first two IQ motifs of myosin V reveals essential recognition features.

• Authors : Houdusse A; Motilité Structurale, Institut Curie, Centre National de la Recherche Scientifique, Unite Mixté de Recherche 144, 26 rue d'Ulm, 75248, Paris Cedex 05, France.; Gaucher JF

Subjects: Models, Molecular*; Calmodulin/Calmodulin/Calmodulin/*chemistry ; Myosin Type V/Myosin Type V/Myosin Type V/*chemistry

• Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2006 Dec 19; Vol. 103 (51), pp. 19326-31. Date of Electronic Publication: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Print

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Interactions of a new alpha-aminophosphinic derivative inside the active site of TLN (thermolysin): a model for zinc-metalloendopeptidase inhibition.

• Authors : Selkti M; Laboratoire de Cristallographie et RMN Biologiques (UMR 8015 CNRS), 4 Avenue de l'Observatoire, 75270 Paris CEDEX 06, France. ; Tomas A

Subjects: Metalloendopeptidases/Metalloendopeptidases/Metalloendopeptidases/*antagonists & inhibitors ; Organophosphorus Compounds/Organophosphorus Compounds/Organophosphorus Compounds/*chemistry ; Thermolysin/Thermolysin/Thermolysin/*chemistry

• Source: Acta crystallographica. Section D, Biological crystallography [Acta Crystallogr D Biol Crystallogr] 2003 Jul; Vol. 59 (Pt 7), pp. 1200-5. Date of Electronic Publication: 2003 Jun Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 9305878 Publication Model: Print-Electronic Cited Medium: Print ISSN:

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The 2.2 A resolution structure of thermolysin (TLN) crystallized in the presence of potassium thiocyanate.

• Authors : Gaucher JF; Laboratoire de Cristallographie et RMN Biologiques (UMR-8015, CNRS), Université Paris V, Faculté de Pharmacie, 4 Avenue de l'Observatoire, 75270 Paris CEDEX 06, France. ; Selkti M

Subjects: Thermolysin/Thermolysin/Thermolysin/*chemistry ; Thiocyanates/Thiocyanates/Thiocyanates/*chemistry; Bacillus/Bacillus/Bacillus/enzymology

• Source: Acta crystallographica. Section D, Biological crystallography [Acta Crystallogr D Biol Crystallogr] 2002 Dec; Vol. 58 (Pt 12), pp. 2198-200. Date of Electronic Publication: 2002 Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 9305878 Publication Model: Print-Electronic Cited Medium: Print ISSN:

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High resolution x-ray analysis of two mutants of a curaremimetic snake toxin.

• Authors : Gaucher JF; Laboratoire d'Enzymologie et de Biochimie Structurales, UPR 9063 CNRS, 91198 Gif-sur-Yvette, France.; Ménez R

Subjects: Erabutoxins/Erabutoxins/Erabutoxins/*chemistry ; Protein Isoforms/Protein Isoforms/Protein Isoforms/*chemistry ; Snake Venoms/Snake Venoms/Snake Venoms/*chemistry

• Source: European journal of biochemistry [Eur J Biochem] 2000 Mar; Vol. 267 (5), pp. 1323-9.Publisher: Blackwell Science Ltd. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 0107600 Publication Model:

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Crystal structures of alpha-mercaptoacyldipeptides in the thermolysin active site: structural parameters for a Zn monodentation or bidentation in metalloendopeptidases.

• Authors : Gaucher JF; Laboratoire de Cristallographie & RMN Biologiques, CNRS EP 2075, UFR des Sciences Pharmaceutiques et Biologiques, 4 Avenue de l'Observatoire, 75270 Paris Cedex 06, France.; Selkti M

Subjects: Dipeptides/Dipeptides/Dipeptides/*chemistry ; Metalloendopeptidases/Metalloendopeptidases/Metalloendopeptidases/*chemistry ; Thermolysin/Thermolysin/Thermolysin/*chemistry

• Source: Biochemistry [Biochemistry] 1999 Sep 28; Vol. 38 (39), pp. 12569-76.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print Cited Medium: Print ISSN:

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Structures of escherichia coli CMP kinase alone and in complex with CDP: a new fold of the nucleoside monophosphate binding domain and insights into cytosine nucleotide specificity.

• Authors : Briozzo P; Laboratoire de Chimie Biologique Institut National Agronomique Paris-Grignon 78850 Thiverval-Grignon France. -gif.fr; Golinelli-Pimpaneau B

Subjects: Cytidine Diphosphate/Cytidine Diphosphate/Cytidine Diphosphate/*chemistry ; Escherichia coli/Escherichia coli/Escherichia coli/*enzymology ; Nucleoside-Phosphate Kinase/Nucleoside-Phosphate Kinase/Nucleoside-Phosphate Kinase/*chemistry

• Source: Structure (London, England : 1993) [Structure] 1998 Dec 15; Vol. 6 (12), pp. 1517-27.Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print Cited Medium: Print ISSN: 0969-2126

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Solubility diagram of the Rhodobacter sphaeroides reaction center as a function of PEG concentration.

• Authors : Gaucher JF; Laboratoire d'Enzymologie et de Biochimie Structurales, CNRS, Gif-sur-Yvette, France.; Riès-Kautt M

Subjects: Photosynthetic Reaction Center Complex Proteins/Photosynthetic Reaction Center Complex Proteins/Photosynthetic Reaction Center Complex Proteins/*metabolism ; Polyethylene Glycols/Polyethylene Glycols/Polyethylene Glycols/*pharmacology ; Rhodobacter sphaeroides/Rhodobacter sphaeroides/Rhodobacter sphaeroides/*metabolism

• Source: FEBS letters [FEBS Lett] 1997 Jan 20; Vol. 401 (2-3), pp. 113-6.Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 0155157 Publication Model: Print Cited Medium: Print ISSN: 0014-5793

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Structure of the photochemical reaction centre of a spheroidene-containing purple-bacterium, Rhodobacter sphaeroides Y, at 3 A resolution.

• Authors : Arnoux B; Laboratoire de Biologie Structurale, CNRS, Gif-sur-Yvette, France.; Gaucher JF

• Source: Acta crystallographica. Section D, Biological crystallography [Acta Crystallogr D Biol Crystallogr] 1995 May 01; Vol. 51 (Pt 3), pp. 368-79.Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 9305878 Publication Model: Print Cited Medium: Print ISSN: 0907-4449

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